C₃₂H₄₂INO₄Si

Base Information

• Chemical Name: C₃₂H₄₂INO₄Si
• CAS No.: 913365-65-8
• Molecular Formula: C₃₂H₄₂INO₄Si
• Molecular Weight: 659.68
• Mol file: 913365-65-8.mol

Synonyms:C₃₂H₄₂INO₄Si

Chemical Property of C₃₂H₄₂INO₄Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₄₂INO₄Si

There total 2 articles about C₃₂H₄₂INO₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3S,4S)-2,3,5-Tris-benzyloxy-4-hydroxy-pentanal oxime (913365-64-7) + tert-butyldimethylsilyl chloride (18162-48-6) → C32H42INO4Si + C32H42INO4Si (913365-65-8)

Guidance literature:

(2S,3S,4S)-2,3,5-Tris-benzyloxy-4-hydroxy-pentanal oxime; tert-butyldimethylsilyl chloride; In pyridine; at 20 ℃; for 36h;

With 1H-imidazole; iodine; thiamine diphosphate; In toluene; for 3h; Heating;

DOI:10.1016/j.tetlet.2006.07.120

Reference yield:

2,3,5-tri-O-benzyl-L-arabinofuranose (96192-07-3) → C32H42INO4Si (913365-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 95 percent / hydroxylamine hydrochloride; NaHCO₃ / ethanol / 2 h / Heating

2.1: pyridine / 36 h / 20 °C

2.2: I₂; TPP; imidazole / toluene / 3 h / Heating

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In pyridine; ethanol;

DOI:10.1016/j.tetlet.2006.07.120

Reference yield: 89.0%

C32H42INO4Si (913365-65-8) → (2S,3S,4S)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-3,4-dihydro-2H-pyrrole-1-oxide (904893-22-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In toluene; for 3h; Heating;

DOI:10.1016/j.tetlet.2006.07.120

upstream raw materials:

(2S,3S,4S)-2,3,5-Tris-benzyloxy-4-hydroxy-pentanal oxime

tert-butyldimethylsilyl chloride

2,3,5-tri-O-benzyl-L-arabinofuranose

Downstream raw materials:

(2S,3S,4S)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-3,4-dihydro-2H-pyrrole-1-oxide

(2S,3S,4S,5S)-2-benzyloxymethyl-3,4-dibenzyloxy-5-(4-benzyloxyphenyl)-N-hydroxy-pyrrolidine

(2S,3S,4S,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-(4-benzyloxy-phenyl)-pyrrolidine

(2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine