4',6'-bis(benzoyloxy)-3'-(3-bromo-3-methylbutyl)-2'-hydroxyacetophenone

Base Information

• Chemical Name: 4',6'-bis(benzoyloxy)-3'-(3-bromo-3-methylbutyl)-2'-hydroxyacetophenone
• CAS No.: 153399-43-0
• Molecular Formula: C₂₇H₂₅BrO₆
• Molecular Weight: 525.396
• Mol file: 153399-43-0.mol

Synonyms:4',6'-bis(benzoyloxy)-3'-(3-bromo-3-methylbutyl)-2'-hydroxyacetophenone

Chemical Property of 4',6'-bis(benzoyloxy)-3'-(3-bromo-3-methylbutyl)-2'-hydroxyacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4',6'-bis(benzoyloxy)-3'-(3-bromo-3-methylbutyl)-2'-hydroxyacetophenone

There total 6 articles about 4',6'-bis(benzoyloxy)-3'-(3-bromo-3-methylbutyl)-2'-hydroxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C28H28O7 (153399-42-9) → 4',6'-bis(benzoyloxy)-3'-(3-bromo-3-methylbutyl)-2'-hydroxyacetophenone (153399-43-0)

Guidance literature:

With boron tribromide; In dichloromethane; at -70 ℃; for 0.5h;

DOI:10.1246/cl.1993.1895

Reference yield:

1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone (18065-05-9) → 4',6'-bis(benzoyloxy)-3'-(3-bromo-3-methylbutyl)-2'-hydroxyacetophenone (153399-43-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 83 percent / I₂, silver trifluoroacetate / CHCl₃ / Ambient temperature

2: K₂CO₃ / acetone

3: 95 percent / PdCl₂, CuI, PPh₃, Et₃N / dimethylformamide / 15 h / 80 - 85 °C

4: H₂ / Pd/C / methanol / 20 °C

5: K₂CO₃ / acetone

6: 79 percent / BBr₃ / CH₂Cl₂ / 0.5 h / -70 °C

With copper(l) iodide; hydrogen; iodine; silver trifluoroacetate; boron tribromide; potassium carbonate; triethylamine; triphenylphosphine; palladium dichloride; palladium on activated charcoal; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;

DOI:10.1246/cl.1993.1895

Reference yield:

3-Iod-2-hydroxy-4,6-dibenzyloxy-acetophenon (95165-66-5) → 4',6'-bis(benzoyloxy)-3'-(3-bromo-3-methylbutyl)-2'-hydroxyacetophenone (153399-43-0)

Guidance literature:

Multi-step reaction with 5 steps

1: K₂CO₃ / acetone

2: 95 percent / PdCl₂, CuI, PPh₃, Et₃N / dimethylformamide / 15 h / 80 - 85 °C

3: H₂ / Pd/C / methanol / 20 °C

4: K₂CO₃ / acetone

5: 79 percent / BBr₃ / CH₂Cl₂ / 0.5 h / -70 °C

With copper(l) iodide; hydrogen; boron tribromide; potassium carbonate; triethylamine; triphenylphosphine; palladium dichloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1246/cl.1993.1895

upstream raw materials:

C₂₈H₂₈O₇

1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone

3-Iod-2-hydroxy-4,6-dibenzyloxy-acetophenon

3'-(3-hydroxy-3-methylbutyl)-4',6'-dihydroxyacetophenone

Downstream raw materials:

C₃₂H₃₂O₆

1-<2',4'-dihydroxy-6-(3''-methyl-2''-butenyloxy)-5'-(3''-methyl-2''-butenyl)>phenylethanone