18065-05-9 Usage
Description
1-(2,4-bis(Benzyloxy)-6-hydroxyphenyl)ethanone is an organic compound with a unique molecular structure that features a phenyl group with benzyloxy substituents at the 2nd and 4th positions, and a hydroxyl group at the 6th position. 1-(2,4-bis (benzyloxy)-6-hydroxyphenyl) ethanone is known for its potential applications in various fields due to its chemical properties.
Uses
1. Used in Pharmaceutical Industry:
1-(2,4-bis(Benzyloxy)-6-hydroxyphenyl)ethanone is used as a reactant for the synthesis of fluorine-containing chalcone derivatives. These derivatives exhibit antiproliferative activity, making them valuable in the development of new drugs and therapies for various medical conditions.
2. Used in Chemical Synthesis:
In the field of chemical synthesis, 1-(2,4-bis(Benzyloxy)-6-hydroxyphenyl)ethanone serves as an important intermediate compound. Its unique structure allows for further modification and functionalization, leading to the creation of a wide range of novel compounds with diverse applications in various industries.
3. Used in Research and Development:
Due to its potential applications in pharmaceuticals and chemical synthesis, 1-(2,4-bis(Benzyloxy)-6-hydroxyphenyl)ethanone is also used in research and development. Scientists and researchers utilize this compound to explore new reaction pathways, develop innovative synthetic methods, and investigate its properties for potential use in various applications.
Preparation
Preparation by reaction of benzyl chloride on phloroacetophenone with potassium carbonate in refluxing acetone (29%), (20%), in DMF at 100° (54%) and at 150–153° (26%) or in HMPA at 90–93° (80%).
Check Digit Verification of cas no
The CAS Registry Mumber 18065-05-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,0,6 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18065-05:
(7*1)+(6*8)+(5*0)+(4*6)+(3*5)+(2*0)+(1*5)=99
99 % 10 = 9
So 18065-05-9 is a valid CAS Registry Number.
InChI:InChI=1/C22H20O4/c1-16(23)22-20(24)12-19(25-14-17-8-4-2-5-9-17)13-21(22)26-15-18-10-6-3-7-11-18/h2-13,24H,14-15H2,1H3
18065-05-9Relevant articles and documents
Synthesis and antiproliferative activity of benzofuran-based analogs of cercosporamide against non-small cell lung cancer cell lines
Bazin, Marc-Antoine,Bodero, Lizeth,Tomasoni, Christophe,Rousseau, Bénédicte,Roussakis, Christos,Marchand, Pascal
, p. 823 - 832 (2013)
A novel series of 3-methyl-1-benzofuran derivatives were synthesized and screened in vitro for their antiproliferative activity against two human NSCLC cell lines (NSCLC-N6 mutant p53 and A549 wild type p53). Most promising compounds presented a structural analogy with the west part of cercosporamide, a natural product of biological interest. In particular, compounds 10, 12 and 31 showed cytotoxic activities at micromolar concentrations (IC50 50 values (25-40 μM).
Biological Investigation of a Water-Soluble Isoginkgetin-Phosphate Analogue, Targeting the Spliceosome with In Vivo Antitumor Activity
Letribot, Boris,Nascimento, Megane,Cerrato, Giulia,Darrigrand, Romain,Salgues, Valerie,Renko, Dolor,Pruvost, Alain,Alami, Mouad,Messaoudi, Samir,Apcher, Sebastien
, p. 4633 - 4648 (2022/03/27)
The first total synthesis of the natural product Isoginkgetin as well as four water-soluble Isoginkgetin-phosphate analogues is reported herein. Moreover, the full study of the IP2 phosphate analogue with respect to pharmacological properties (metabolic and plasmatic stabilities, pharmacokinetic, off-target, etc.) as well as in vitro and in vivo biological activities are disclosed herein.
Synthesis and Biological Evaluation of 4-Substituted Kaempfer-3-ols
Kim, Sugyeom,Lannigan, Deborah A.,Li, Yu,Lin, Lin,O'Doherty, George A.,Sayasith, Peyton R.,Tarr, Ariel T.,Wright, Eric B.,Yasmin, Sharia
, p. 4279 - 4288 (2020/04/09)
The synthesis of two series of five kaempfer-3-ols was described. The first set all have a C-3 hydroxyl group and the second has a carboxymethoxy ether at the C-3 position. Both series have variable substitution at the C-4 position (i.e., OH, Cl, F, H, OMe). Both kaempferols and carboxymethoxy ethers were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity and cancer cell proliferation.