(1s,4s)-4-((5-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

Base Information

Chemical Name:(1s,4s)-4-((5-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide
CAS No.:1357922-72-5
Molecular Formula:C₂₅H₄₀N₄O₄
Molecular Weight:460.617
Hs Code.:

Synonyms:(1s,4s)-4-((5-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

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Chemical Property of (1s,4s)-4-((5-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

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Technology Process of (1s,4s)-4-((5-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

There total 3 articles about (1s,4s)-4-((5-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1357923-87-5
2-(1-(3-fluoro-4-nitrobenzyl)piperidin-4-yl)propan-2-ol

: 1357923-26-2
C₁₀H₂₀N₂O*ClH

: 1357922-72-5
(1s,4s)-4-((5-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 24h;
DOI:10.1021/jm3005866

Reference yield:

: 22990-34-7
2-(piperidin-4-yl)propan-2-ol

: 1357922-72-5
(1s,4s)-4-((5-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 0.75 h / 5 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 80 °C

With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm3005866

Reference yield:

: 160538-51-2
3-fluoro-4-nitro-benzaldehyde

: 1357922-72-5
(1s,4s)-4-((5-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 0.75 h / 5 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 80 °C

With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm3005866