22990-34-7

Basic information

• Product Name: 2-(4-PIPERIDYL)-2-PROPANOL
• Synonyms: 4-PIPERIDINEMETHANOL, ALPHA,ALPHA-DIMETHYL-;2-(4-PIPERIDYL)-2-PROPANOL;2-(4-PIPERIDYL)ISOPROPYL ALCOHOL;2-(Piperidin-4-yl)propan-2-ol;2-(4-Piperidyl)isopropyl Alcohol 2-(Piperidin-4-yl)propan-2-ol;2-piperidin-4-ylpropan-2-ol(SALTDATA: FREE);a,a-DiMethyl-4-piperidineMethanol;2-(4-Piperidinyl)-2-propanol
• CAS NO: 22990-34-7
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.23
• Mol File: 22990-34-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 136°C
• Boiling Point: 219.4 °C at 760 mmHg
• Flash Point: 75.8 °C
• Appearance: /
• Density: 0.956 g/cm³
• Vapor Pressure: 0.0251mmHg at 25°C
• Refractive Index: 1.466
• PKA: 15.08±0.29(Predicted)
• CAS DataBase Reference: 2-(4-PIPERIDYL)-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-PIPERIDYL)-2-PROPANOL(22990-34-7)
• EPA Substance Registry System: 2-(4-PIPERIDYL)-2-PROPANOL(22990-34-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 22990-34-7(Hazardous Substances Data)

Usage

Physical Form

Solid

Uses

2-(Piperidin-4-yl)propan-2-ol is a useful research chemical.

InChI:InChI=1/C8H17NO/c1-8(2,10)7-3-5-9-6-4-7/h7,9-10H,3-6H2,1-2H3

Upstream product

• 160809-39-2 1-(benzyloxycarbonyl)-4-(1-hydroxy-1-methylethyl)piperidine 
• 2971-79-1 isonipecotic acid methyl ester 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 1126-09-6 4-carbethoxypiperidine 
• 299428-04-9 N-benzyl-4-(2-hydroxy-2-propyl)piperidine 
• 917-64-6 methyl magnesium iodide 
• 136081-74-8 ethyl 1-benzoyl-4-piperidine-carboxylate 

Downstream Products

• 1028319-82-5 3-(1-(5-(4-(2-hydroxypropan-2-yl)piperidine-1-carbonyl)-4-methylthiazol-2-yl)piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3h)-one 
• 1257385-09-3 (2-(2-cyclopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)(4-(2-hydroxypropan-2-yl)piperidin-1-yl)methanone 
• 1119718-54-5 C₂₅H₃₁N₃O₃ 
• 1227065-29-3 (1H-benzo[d]imidazol-2-yl)(4-(3-(4-(2-hydroxypropan-2-yl)-piperidin-1-yl)pyrazin-2-yloxy)phenyl)methanone 
• 1332075-58-7 2-(1-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol 
• 1258402-41-3 C₂₉H₃₅F₃N₂O₅ 
• 1236047-48-5 4-(2-hydroxy-2-propyl)-N-hydroxypiperidine 
• 1236047-51-0 4-(2-hydroxy-2-propyl)-3,4,5,6-tetrahydropyridine 1-oxide 
• 1231921-30-4 2-(1-(3-(4-(pyridin-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4-yl)propan-2-ol 
• 1190045-91-0 4-(2-hydroxypropan-2-yl)-N-(7-(4-(2-hydroxypropan-2-yl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)benzamide 
• 1145786-33-9 2-(1-{6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinyl}-4-piperidinyl)-2-propanol 
• 1257295-02-5 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-piperidin-4-yl)propan-2-ol 

Relevant articles and documents

Preparation method of 2-(4-piperidyl)-2-propanol and hydrochloride thereof

The invention provides a preparation method of 2-(4-piperidyl)-2-propanol and hydrochloride thereof. The method comprises the following steps: introducing tert-butyloxycarboryl as an amino protectiongroup on a raw material 4-piperidinecarboxylate molecule, carrying out alkylation addition on an ester group in the raw material molecule by using a methyl Grignard reagent, removing a BOC protectiongroup in an acidolysis manner to obtain 2-(4-piperidinyl)-2-propanol hydrochloride, and adding an alkali to adjust the pH value in order to obtain 2-(4-piperidinyl)-2-2-propanol. The preparation method provided by the invention is simple, easy to operate and high in yield, has the cost advantage and is very suitable for industrial production.

Regioselective transformation of 6/5-fused bicyclic isoxazolidines to second-generation cyclic aldonitrones

The cycloaddition reactions of 4-(2-hydroxy-2-propyl)-3,4,5,6- tetrahydropyridine 1-oxide with mono- and di-substituted alkenes have been found to be highly stereo- as well as face-selective. In solution, the 6/5 fused bicyclic cycloadducts remain solely as the cis-fused invertomers in order to accommodate the bulky tertiary substituent 2-hydroxy-2-propyl in the equatorial orientation. The cycloadducts, upon peracid oxidation, leads to the exclusive formation of synthetically important second-generation cyclic aldonitrones. The stereo- and face-selectivity of the cycloaddition reactions of these second-generation nitrones bearing substituents at C(4) and C(6) have been briefly examined. One interesting finding was that treatment of the first generation nitrone i.e., 4-(2-hydroxy-2-propyl)-3,4,5,6-tetrahydropyridine 1-oxide, with mercury(II) oxide afforded a novel bicyclic nitrone, 1-oxa-5,6-dehydro-6-aza-bicyclo[3,2,1]heptane 6-oxide. ARKAT USA, Inc.

PHOSPHODIESTERASE 10 INHIBITORS

The present invention is directed to compounds, useful as PDE10 inhibitors, having the formula where R1,R2, R3, R4, X, Y and z are as defined herein, pharmaceutical compositions containing such compounds. and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like