Technology Process of {4-[(cyclobutyloxy)methyl]-2,6-dimethoxyphenyl}boronic acid
There total 4 articles about {4-[(cyclobutyloxy)methyl]-2,6-dimethoxyphenyl}boronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / Reflux; Cooling with ice
1.2: Cooling with ice
2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 14 h / 20 °C / Cooling with ice
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Cooling with ice
3.2: 1 h / 20 °C
4.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
4.2: 20 °C
4.3: Cooling with ice
With
n-butyllithium; dimethylsulfide borane complex; sodium hydride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
2-bromo-5-[(cyclobutyloxy)methyl]-1,3-dimethoxybenzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
With
Trimethyl borate;
In
tetrahydrofuran; hexane;
at -78 - 35 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Cooling with ice
1.2: 1 h / 20 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: 20 °C
2.3: Cooling with ice
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;
