(R)-N-((R)-2-(5-bromo-2-fluorophenyl)-4-(cyanomethoxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((R)-2-(5-bromo-2-fluorophenyl)-4-(cyanomethoxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide
CAS No.:1400682-90-7
Molecular Formula:C₁₆H₂₀BrF₃N₂O₂S
Molecular Weight:441.312
Hs Code.:

Synonyms:(R)-N-((R)-2-(5-bromo-2-fluorophenyl)-4-(cyanomethoxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((R)-2-(5-bromo-2-fluorophenyl)-4-(cyanomethoxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((R)-2-(5-bromo-2-fluorophenyl)-4-(cyanomethoxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

There total 5 articles about (R)-N-((R)-2-(5-bromo-2-fluorophenyl)-4-(cyanomethoxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310349-96-2
(R)-2-methyl-propane-2-sulfinic acid [(R)-1-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-3-hydroxy-1-methyl-propyl]-amide

: 590-17-0
cyanomethyl bromide

: 1400682-90-7
(R)-N-((R)-2-(5-bromo-2-fluorophenyl)-4-(cyanomethoxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; silver(l) oxide; In dichloromethane; at 22 ℃; for 2h;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1400682-90-7
(R)-N-((R)-2-(5-bromo-2-fluorophenyl)-4-(cyanomethoxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2: zinc / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3: lithium borohydride / tetrahydrofuran / 4 h / 0 °C

4: tetra-(n-butyl)ammonium iodide; silver(l) oxide / dichloromethane / 2 h / 22 °C

With titanium(IV) tetraethanolate; lithium borohydride; tetra-(n-butyl)ammonium iodide; silver(l) oxide; zinc; In tetrahydrofuran; dichloromethane; 2: Reformatsky Reaction;

Reference yield:

: (R)-N-((1E)-1-(5-bromo-2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1400682-90-7
(R)-N-((R)-2-(5-bromo-2-fluorophenyl)-4-(cyanomethoxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1: zinc / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

2: lithium borohydride / tetrahydrofuran / 4 h / 0 °C

3: tetra-(n-butyl)ammonium iodide; silver(l) oxide / dichloromethane / 2 h / 22 °C

With lithium borohydride; tetra-(n-butyl)ammonium iodide; silver(l) oxide; zinc; In tetrahydrofuran; dichloromethane; 1: Reformatsky Reaction;