(S)-2-[Allyl-(3-{[(S)-2-amino-3-(4-tert-butoxy-phenyl)-propionyl]-benzyl-amino}-propionyl)-amino]-3-phenyl-propionic acid

Base Information

• Chemical Name: (S)-2-[Allyl-(3-{[(S)-2-amino-3-(4-tert-butoxy-phenyl)-propionyl]-benzyl-amino}-propionyl)-amino]-3-phenyl-propionic acid
• CAS No.: 444167-85-5
• Molecular Formula: C₃₅H₄₃N₃O₅
• Molecular Weight: 585.744
• Mol file: 444167-85-5.mol

Synonyms:(S)-2-[Allyl-(3-{[(S)-2-amino-3-(4-tert-butoxy-phenyl)-propionyl]-benzyl-amino}-propionyl)-amino]-3-phenyl-propionic acid

Chemical Property of (S)-2-[Allyl-(3-{[(S)-2-amino-3-(4-tert-butoxy-phenyl)-propionyl]-benzyl-amino}-propionyl)-amino]-3-phenyl-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[Allyl-(3-{[(S)-2-amino-3-(4-tert-butoxy-phenyl)-propionyl]-benzyl-amino}-propionyl)-amino]-3-phenyl-propionic acid

There total 1 articles about (S)-2-[Allyl-(3-{[(S)-2-amino-3-(4-tert-butoxy-phenyl)-propionyl]-benzyl-amino}-propionyl)-amino]-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + allyl alcohol (107-18-6) + acryloyl chloride (814-68-6,25189-84-8) + benzylamine (100-46-9) → (S)-2-[Allyl-(3-{[(S)-2-amino-3-(4-tert-butoxy-phenyl)-propionyl]-benzyl-amino}-propionyl)-amino]-3-phenyl-propionic acid (444167-85-5)

Guidance literature:

Multistep reaction.;

DOI:10.1021/ol025988b

Reference yield: 55.0%

(S)-2-[Allyl-(3-{[(S)-2-amino-3-(4-tert-butoxy-phenyl)-propionyl]-benzyl-amino}-propionyl)-amino]-3-phenyl-propionic acid (444167-85-5) → (3S,6S)-7-Allyl-1,6-dibenzyl-3-(4-tert-butoxy-benzyl)-[1,4,7]triazecane-2,5,8-trione (444167-86-6)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 16h;

DOI:10.1021/ol025988b

upstream raw materials:

Fmoc-Tyr(tBu)-OH

allyl alcohol

acryloyl chloride

benzylamine

Downstream raw materials:

(3S,6S)-7-Allyl-1,6-dibenzyl-3-(4-tert-butoxy-benzyl)-[1,4,7]triazecane-2,5,8-trione