1-Benzyl-5-(N-methylformamido)-1H-imidazole-4-carboxamidine Hydrochloride

Base Information

• Chemical Name: 1-Benzyl-5-(N-methylformamido)-1H-imidazole-4-carboxamidine Hydrochloride
• CAS No.: 70276-58-3
• Molecular Formula: C₁₃H₁₅N₅O*ClH
• Molecular Weight: 293.756
• Mol file: 70276-58-3.mol

Synonyms:1-Benzyl-5-(N-methylformamido)-1H-imidazole-4-carboxamidine Hydrochloride

Chemical Property of 1-Benzyl-5-(N-methylformamido)-1H-imidazole-4-carboxamidine Hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-5-(N-methylformamido)-1H-imidazole-4-carboxamidine Hydrochloride

There total 3 articles about 1-Benzyl-5-(N-methylformamido)-1H-imidazole-4-carboxamidine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine (70276-49-2) → 1-Benzyl-5-(N-methylformamido)-1H-imidazole-4-carboxamidine Hydrochloride (70276-58-3)

Guidance literature:

With hydrogenchloride; hydrogen; Raney Ni W-2; In water; for 8h; under 760 Torr; Ambient temperature;

DOI:10.1248/cpb.37.1504

Reference yield:

1-Benzyl-N'-ethoxy-5-formamido-1H-imidazole-4-carboxamidine (70276-43-6,125661-60-1,125661-61-2) → 1-Benzyl-5-(N-methylformamido)-1H-imidazole-4-carboxamidine Hydrochloride (70276-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / anhydrous K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

2: 54 percent / H₂, 1N aqueous HCl / Raney Ni W-2 / H₂O / 8 h / 760 Torr / Ambient temperature

With hydrogenchloride; hydrogen; potassium carbonate; Raney Ni W-2; In water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.37.1504

Reference yield:

9-Benzyl-1-ethoxyadenine hydroiodide (10183-98-9) → 1-Benzyl-5-(N-methylformamido)-1H-imidazole-4-carboxamidine Hydrochloride (70276-58-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / 10percent aqueous Na₂CO₃ / 60 °C

2: 91 percent / anhydrous K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

3: 54 percent / H₂, 1N aqueous HCl / Raney Ni W-2 / H₂O / 8 h / 760 Torr / Ambient temperature

With hydrogenchloride; hydrogen; sodium carbonate; potassium carbonate; Raney Ni W-2; In water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.37.1504

upstream raw materials:

1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine

1-Benzyl-N'-ethoxy-5-formamido-1H-imidazole-4-carboxamidine

9-Benzyl-1-ethoxyadenine hydroiodide