1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine

Base Information

• Chemical Name: 1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine
• CAS No.: 70276-49-2
• Molecular Formula: C₁₅H₁₉N₅O₂
• Molecular Weight: 301.348
• Mol file: 70276-49-2.mol

Synonyms:1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine

Chemical Property of 1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine

There total 3 articles about 1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-Benzyl-N'-ethoxy-5-formamido-1H-imidazole-4-carboxamidine (70276-43-6,125661-60-1,125661-61-2) + methyl iodide (74-88-4) → 1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine (70276-49-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 3h; Ambient temperature;

DOI:10.1248/cpb.37.1504

Reference yield:

9-Benzyl-1-ethoxyadenine hydroiodide (10183-98-9) → 1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine (70276-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 10percent aqueous Na₂CO₃ / 60 °C

2: 91 percent / anhydrous K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

With sodium carbonate; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.37.1504

Reference yield:

→ 1-Benzyl-N'-ethoxy-5-(N-methylformamido)-1H-imidazole-4-carboxamidine (70276-49-2)

Guidance literature:

Na-Salz von (II) , Methyliodid, K2CO3, DMF;

DOI:10.1016/S0040-4039(01)85794-4

upstream raw materials:

1-Benzyl-N'-ethoxy-5-formamido-1H-imidazole-4-carboxamidine

methyl iodide

9-Benzyl-1-ethoxyadenine hydroiodide

Downstream raw materials:

9-Benzyl-3-methyladenine Perchlorate

1-Benzyl-5-(N-methylformamido)-1H-imidazole-4-carboxamidine Hydrochloride