O-Benzyl-alpha-methyl-L-Tyr

Base Information

Chemical Name:O-Benzyl-alpha-methyl-L-Tyr
CAS No.:77457-02-4
Molecular Formula:C₁₇H₁₉NO₃
Molecular Weight:285.343
Hs Code.:
DSSTox Substance ID:DTXSID801289023

Synonyms:77457-02-4;(S)-2-amino-3-(4-(benzyloxy)phenyl)-2-methylpropanoic acid;O-Benzyl-alpha-methyl-L-Tyr;SCHEMBL9079869;DTXSID801289023;AKOS030212896;alpha-Methyl-O-(phenylmethyl)-L-tyrosine;O-Benzyl-|A inverted exclamation mark-methyl-L-Tyr

Suppliers and Price of O-Benzyl-alpha-methyl-L-Tyr

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of O-Benzyl-alpha-methyl-L-Tyr

Chemical Property:

XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:285.13649347
Heavy Atom Count:21
Complexity:333

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)(C(=O)O)N
Isomeric SMILES:C[C@](CC1=CC=C(C=C1)OCC2=CC=CC=C2)(C(=O)O)N

Technology Process of O-Benzyl-alpha-methyl-L-Tyr

There total 6 articles about O-Benzyl-alpha-methyl-L-Tyr which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 672-86-6,5380-13-2
α-methyl-p-tyrosine

: 77457-02-4
(S)-O-benzyl-α-methyltyrosine

Guidance literature:: With potassium carbonate; In tetrahydrofuran;

Reference yield:

: benzyl (S)-3-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)-2-methylpropanoate

: 77457-02-4
(S)-O-benzyl-α-methyltyrosine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / water; ethanol / 0.25 h / 70 °C

2: trifluoroacetic acid; chlorotriisopropylsilane / dichloromethane / 0.25 h

With chlorotriisopropylsilane; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1021/acs.jmedchem.0c01941

Reference yield:

: 672-87-7,5380-13-2
L-methyltyrosine

: 77457-02-4
(S)-O-benzyl-α-methyltyrosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / Inert atmosphere

1.2: Inert atmosphere

1.3: 0.5 h / Inert atmosphere

2.1: potassium carbonate / acetonitrile / 1 h / 90 °C

3.1: potassium hydroxide / water; ethanol / 0.25 h / 70 °C

4.1: trifluoroacetic acid; chlorotriisopropylsilane / dichloromethane / 0.25 h

With chloro-trimethyl-silane; chlorotriisopropylsilane; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/acs.jmedchem.0c01941