rac-3-{4-[(E)-3-(2,5-difluoro-phenyl)-allylamino]-piperidin-1-yl}-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol

Base Information

Chemical Name:rac-3-{4-[(E)-3-(2,5-difluoro-phenyl)-allylamino]-piperidin-1-yl}-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol
CAS No.:1192282-11-3
Molecular Formula:C₂₇H₃₀F₃N₃O₂
Molecular Weight:485.549
Hs Code.:

Synonyms:rac-3-{4-[(E)-3-(2,5-difluoro-phenyl)-allylamino]-piperidin-1-yl}-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol

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Chemical Property of rac-3-{4-[(E)-3-(2,5-difluoro-phenyl)-allylamino]-piperidin-1-yl}-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol

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Technology Process of rac-3-{4-[(E)-3-(2,5-difluoro-phenyl)-allylamino]-piperidin-1-yl}-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol

There total 2 articles about rac-3-{4-[(E)-3-(2,5-difluoro-phenyl)-allylamino]-piperidin-1-yl}-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 872263-26-8
(E)-3-(2,5-difluorophenyl)acrylaldehyde

: 1192282-10-2
rac-3-(4-amino-piperidin-1-yl)-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol

: 1192282-11-3
rac-3-{4-[(E)-3-(2,5-difluoro-phenyl)-allylamino]-piperidin-1-yl}-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol

Guidance literature:: (2E)-3-(2,5-difluorophenyl)acrylaldehyde; rac-3-(4-amino-piperidin-1-yl)-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol; In methanol; 1,2-dichloro-ethane; at 50 ℃; Molecular sieve;

With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 0.666667h;

Reference yield:

: 944407-21-0
rac-{1-[2-(7-fluoro-2-methoxy-quinolin-8-yl)-3-hydroxy-propyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

: 1192282-11-3
rac-3-{4-[(E)-3-(2,5-difluoro-phenyl)-allylamino]-piperidin-1-yl}-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

1.2: pH 12

2.1: 1,2-dichloro-ethane; methanol / 50 °C / Molecular sieve

2.2: 0.67 h / 0 °C

With trifluoroacetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane;