872263-26-8

Usage

Classification

alpha,beta-unsaturated aldehyde

Uses

organic synthesis, pharmaceutical research, production of pharmaceuticals and agricultural chemicals, synthesis of organic compounds, precursor in production of fragrances and flavorings

Configuration

(2E)indicates the arrangement of substituents on C=C double bond, with substituents on opposite sides of the bond

Upstream product

• 1007862-01-2 methyl (2E)-3-(2,5-difluorophenyl)-2-propenoate 
• 375368-91-5 ethyl (E)-3-(2,5-difluorophenyl)acrylate 
• 112898-33-6 3-(2,5-difluorophenyl)acrylic acid 
• 767355-26-0 trans-3-(2,5-difluoro-phenyl)-prop-2-en-1-ol 
• 2646-90-4 2,5-difluorobenzaldehyde 
• 2136-75-6 (triphenylphosphoranylidene)acetaldehyde 

Downstream Products

• 872263-23-5 ethyl (RS)-2-{[(E)-3-(2,5-difluorophenyl)allyl-amino]methyl}-5-(3-fluoro-6-methoxyquinolin-4-yl)-pentanoate 
• 1192282-11-3 rac-3-{4-[(E)-3-(2,5-difluoro-phenyl)-allylamino]-piperidin-1-yl}-2-(7-fluoro-2-methoxy-quinolin-8-yl)-propan-1-ol 
• 1093218-54-2 {(3R,6S)-6-[(1S)-1-amino-2-(6-methoxy[1,5]naphthyridin-4-yl)-ethyl]-tetrahydropyran-3-yl}-[3-(2,5-difluorophenyl)-allyl]-amine 
• 1093218-81-5 {(3R,6S)-6-[(1R)-1-amino-2-(6-methoxy[1,5]naphthyridin-4-yl)-ethyl]-tetrahydropyran-3-yl}-[(E)-3-(2,5-difluorophenyl)-allyl]-amine 
• 1192282-13-5 rac-[(E)-3-(2,5-difluoro-phenyl)-allyl]-[1-(2-methoxy-8,9-dihydro-furo[2,3-h]quinolin-9-ylmethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester 
• 1192282-12-4 rac-[(E)-3-(2,5-difluoro-phenyl)-allyl]-{1-[2-(7-fluoro-2-methoxy-quinolin-8-yl)-3-hydroxy-propyl]-piperidin-4-yl}-carbamic acid tert-butyl ester 
• 1197396-81-8 (1R)-1-[(4-{[(2E)-3-(2,5-difluorophenyl)-2-propen-1-yl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione 
• 1093219-10-3 [(1RS)-1-{(2S,5R)-5-[(E)-3-(2,5-difluoro-phenyl)-allylamino]-tetrahydropyran-2-yl}-2-(6-methoxy[1,5]naphthyridin-4-yl)-ethyl]-carbamic acid benzyl ester 
• 1073495-60-9 (1R)-1-[(4-{[(2E)-3-(2,5-difluorophenyl)-2-propen-1-yl]amino}-1-piperidinyl)methyl]-9-fluoro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one 
• 950510-61-9 (E)-2-{(2R,3R,6R)-3-[3-(2,5-difluoro-phenyl)-allylamino]-6-[2-(6-methoxy-[1,5]naphthyridin-4-yl)-ethyl]-tetrahydro-pyran-2-yl}-ethanol 

Relevant academic research and scientific papers

Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

There is an emerging global need for new and more effective antibiotics against multi-resistant bacteria. This situation has led to massive industrial investigations on novel bacterial topoisomerase inhibitors (NBTIs) that target the vital bacterial enzym

Tubulin inhibitor

The invention provides a novel tubulin inhibitor and an application thereof. The novel tubulin inhibitor is a series of substituted heterocyclic skeleton-based compounds with colchicine binding sites in tubulins as targets. The compounds have the following structure as shown in the specification, wherein the formula is as shown in the specification; n independently represents an integer of 0-5 under the condition that n is less than or equal to 5; A represents a monosubstituted or polysubstituted group; and the group is selected from H, C1-C20 acylamino, C1-C20 acyloxy, C1-C20 alkanoyl, C1-C20 alkoxycarbonyl, C1-C20 alkoxy, C1-C20 alkylamino, C1-C20 alkylcarboxy amino, aroyl, arylalkanoyl, carboxyl, cyano, halogen, hydroxyl, nitro and methylthienyl.

4-(1-AMINO-ETHYL)-CYCLOHEXYLAMINE DERIVATIVES

The invention relates to compounds of formula (I) wherein R0 represents H or OH; R1 represents alkoxy; U and W represent N, V represents CH and R2 represents H or F, or U and V represent CH, W represents N and R2 /su

TRICYCLIC NITROGEN CONTAINING COMPOUNDS AND THEIR USE AS ANTIBACTERIALS

Compounds of Formula (I) or a pharmaceutically acceptable salt or N-oxide thereof; Formula (I) (relative stereochemistry shown) wherein: Z1, Z2 , L are as defined, U represents a cyclic group selected from: phenyl, pyridyl, pyridazin

3-AMINO-6-(1-AMINO-ETHYL)-TETRAHYDROPYRAN DERIVATIVES

The invention relates to antibacterial compounds of formula I wherein R1 represents halogen or alkoxy; U and W each represent N, V represents CH and R2 represents H or F, or U and V each represent CH, W represents N and R2

4-(1-AMINO-ETHYL)-CYCLOHEXYLAMINE DERIVATIVES

The invention relates to compounds of formula (I) wherein R0 represents H or OH; R1 represents alkoxy; U and W represent N, V represents CH and R2 represents H or F, or U and V represent CH, W represents N and R2/sup

TRICYCLIC COMPOUNDS AS ANTIBACTERIALS

Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.

4-Substituted Quinoline Derivatives, Method and Intermediates for Their Preparation and Pharmaceutical Compositions Containing Them

The present invention relates to 4-substituted quinoline derivatives of general formula I: which are active as antimicrobials. The invention also relates to the method and intermediates for their preparation and the pharmaceutical compositions containing

ETHANOL OR 1,2-ETHANEDIOL CYCLOHEXYL ANTIBIOTIC DERIVATIVES

The invention relates to antibiotic ethanol or 1,2-ethanediol cyclohexyl derivatives of formula (I) wherein R1 represents (C1-C4)alkoxy; one or two of U, V, W and X represent(s) N and the remaining represent each independently CH or, in the case of V or X

New Piperidine Antibiotics

The invention relates to novel, antibacterially active piperidine derivatives of the formula wherein one of U and V represents N, the other represents N or CH; M represents CH2CH2, CH═CH, CH(OH)CH(OH), CH(OH)CH2, CH(NHsub