5-[(4-chlorophenylamino)(methylthio)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane

Base Information

• Chemical Name: 5-[(4-chlorophenylamino)(methylthio)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane
• CAS No.: 123419-95-4
• Molecular Formula: C₁₄H₁₄ClNO₄S
• Molecular Weight: 327.788
• Mol file: 123419-95-4.mol

Synonyms:5-[(4-chlorophenylamino)(methylthio)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane

Chemical Property of 5-[(4-chlorophenylamino)(methylthio)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[(4-chlorophenylamino)(methylthio)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane

There total 4 articles about 5-[(4-chlorophenylamino)(methylthio)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-[bis(methylthio)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione (100981-05-3) + 4-chloro-aniline (106-47-8) → 5-[(4-chlorophenylamino)(methylthio)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane (123419-95-4)

Guidance literature:

In chloroform; at 60 ℃; for 1.5h; Heating;

DOI:10.1002/jhet.5570390102

Reference yield: 54.0%

cycl-isopropylidene malonate (2033-24-1) + 4-Chlorophenyl isothiocyanate (2131-55-7) + methyl iodide (74-88-4) → 5-[(4-chlorophenylamino)(methylthio)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane (123419-95-4)

Guidance literature:

cycl-isopropylidene malonate; With lithium hydride; In dimethyl sulfoxide; at 20 ℃; for 1h;

4-Chlorophenyl isothiocyanate; for 12h;

methyl iodide; for 4h;

DOI:10.1002/jhet.5570390102

Reference yield:

5-[(4-Chloro-phenylamino)-mercapto-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione + methyl iodide (74-88-4) → 5-[(4-chlorophenylamino)(methylthio)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane (123419-95-4)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

5-[bis(methylthio)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione

4-chloro-aniline

cycl-isopropylidene malonate

4-Chlorophenyl isothiocyanate

Downstream raw materials:

5-[(4-chloro-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

5-[(anilino)(4-chlorophenylamino)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane

5-[Amino-(4-chloro-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

N-(4-Chloro-phenyl)-6-methoxy-2,2-dimethyl-4-oxo-4H-[1,3]dioxine-5-carboximidothioic acid methyl ester