5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methylthiazolidin-2-one

Base Information

Chemical Name:5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methylthiazolidin-2-one
CAS No.:1370452-28-0
Molecular Formula:C₃₀H₂₅F₁₀NO₂S
Molecular Weight:653.584
Hs Code.:

Synonyms:5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methylthiazolidin-2-one

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Chemical Property of 5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methylthiazolidin-2-one

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Technology Process of 5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methylthiazolidin-2-one

There total 8 articles about 5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methylthiazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875548-98-4
2'-(bromomethyl)-4-fluoro-2-methoxy-5-(propan-2-yl)-4'-(trifluoromethyl)biphenyl

: 1370452-46-2
C₁₂H₉F₆NOS

: 1370452-28-0
5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methylthiazolidin-2-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

Reference yield:

: 401-95-6
3,5-Bis(trifluoromethyl)benzaldehyde

: 1370452-28-0
5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methylthiazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / ethanol; water / 1 h / 0 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: triphenylphosphine; tiolacetic acid; diethylazodicarboxylate / tetrahydrofuran / -10 - 20 °C

3.1: hydrogen; formic acid / Raney nickel / water; methanol / 20 °C / 775.74 Torr

3.2: pH 9 - 10

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 5 h / 80 °C

With formic acid; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tiolacetic acid; sodium hydroxide; diethylazodicarboxylate; Raney nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 944317-92-4
1-bromo-4-fluoro-2-methoxy-5-(propan-2-yl)-benzene

: 1370452-28-0
5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methylthiazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Reflux

2: lithium aluminium tetrahydride / diethyl ether / 10 h / Inert atmosphere; Reflux

3: sulfuric acid; hydrogen bromide / dichloromethane; acetic acid / Cooling with ice; Reflux

4: sodium hydride / N,N-dimethyl-formamide / 5 h / 80 °C

With lithium aluminium tetrahydride; sulfuric acid; hydrogen bromide; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; N,N-dimethyl-formamide;