(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-((2E,4E)-octa-2,4-dienoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-6-methoxy-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(triethylsilyloxy)butanoic acid

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Chemical Name:(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-((2E,4E)-octa-2,4-dienoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-6-methoxy-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(triethylsilyloxy)butanoic acid
CAS No.:1103935-87-0
Molecular Formula:C₆₉H₁₀₂O₁₈Si
Molecular Weight:1247.64
Hs Code.:

(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-((2E,4E)-octa-2,4-dienoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-6-methoxy-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(triethylsilyloxy)butanoic acid

Synonyms:(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-((2E,4E)-octa-2,4-dienoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-6-methoxy-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(triethylsilyloxy)butanoic acid

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Chemical Property of (R)-4-((2S,4S,6S)-4-acetoxy-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-((2E,4E)-octa-2,4-dienoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-6-methoxy-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(triethylsilyloxy)butanoic acid

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Technology Process of (R)-4-((2S,4S,6S)-4-acetoxy-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-((2E,4E)-octa-2,4-dienoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-6-methoxy-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(triethylsilyloxy)butanoic acid

There total 1 articles about (R)-4-((2S,4S,6S)-4-acetoxy-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-((2E,4E)-octa-2,4-dienoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-6-methoxy-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(triethylsilyloxy)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 994-30-9
triethylsilyl chloride

: 1190429-44-7
C₆₃H₈₈O₁₈

: 1103935-87-0
(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-((2E,4E)-octa-2,4-dienoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-6-methoxy-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(triethylsilyloxy)butanoic acid

Guidance literature:: With dmap; In dichloromethane; at -15 - 0 ℃; for 2h;
DOI:10.1021/ol8027253

Reference yield: 62.0%

: 1103935-87-0
(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-((2E,4E)-octa-2,4-dienoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-6-methoxy-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(triethylsilyloxy)butanoic acid

: 1103935-99-4
C₆₁H₉₂O₁₆Si

Guidance literature:: (R)-4-((2S,4S,6S)-4-acetoxy-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-((2E,4E)-octa-2,4-dienoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-6-methoxy-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(triethylsilyloxy)butanoic acid; With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; tert-butyl alcohol; at 0 ℃; for 2h; aq. phosphate buffer;

With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

With dmap; In tetrahydrofuran; toluene; at 40 ℃; for 14h;
DOI:10.1021/ol8027253