(3R,4S)-3-(benzyloxycarbonylamino)-4-methylhexyl methanesulfonate

Base Information

• Chemical Name: (3R,4S)-3-(benzyloxycarbonylamino)-4-methylhexyl methanesulfonate
• CAS No.: 1616868-46-2
• Molecular Formula: C₁₆H₂₅NO₅S
• Molecular Weight: 343.444
• Mol file: 1616868-46-2.mol

Synonyms:(3R,4S)-3-(benzyloxycarbonylamino)-4-methylhexyl methanesulfonate

Chemical Property of (3R,4S)-3-(benzyloxycarbonylamino)-4-methylhexyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4S)-3-(benzyloxycarbonylamino)-4-methylhexyl methanesulfonate

There total 9 articles about (3R,4S)-3-(benzyloxycarbonylamino)-4-methylhexyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H23NO3 + methanesulfonyl chloride (124-63-0) → (3R,4S)-3-(benzyloxycarbonylamino)-4-methylhexyl methanesulfonate (1616868-46-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2014.05.098

Reference yield:

C18H25NO6 → (3R,4S)-3-(benzyloxycarbonylamino)-4-methylhexyl methanesulfonate (1616868-46-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0.33 h / 0 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.tet.2014.05.098

Reference yield:

(3R,4S)-4-methyl-3-({[(phenylmethyl)oxy]carbonyl}amino)hexanoic acid (872423-93-3) → (3R,4S)-3-(benzyloxycarbonylamino)-4-methylhexyl methanesulfonate (1616868-46-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 0 °C

2: sodium tetrahydroborate / methanol / 0.33 h / 0 °C

3: triethylamine / dichloromethane / 0 - 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tet.2014.05.098

upstream raw materials:

N-benzyloxycarbonylamino-D-alloisoleucine

methanesulfonyl chloride

benzyl (S)-(1-diazo-4-methyl-2-oxohexan-2-yl)carbamate

(3R,4S)-4-methyl-3-({[(phenylmethyl)oxy]carbonyl}amino)hexanoic acid

Downstream raw materials:

(3R,4S)-3-benzyloxycarbonylamino-4-methylhexane-1-sulfonic acid

(3R,4S)-S-3-(benzyloxycarbonylamino)-4-methylhexyl ethanethioate