7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride

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Chemical Name:7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride
CAS No.:1261105-97-8
Molecular Formula:C₂₈H₂₈N₈O
Molecular Weight:492.583
Hs Code.:

Synonyms:7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride

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Chemical Property of 7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride

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Technology Process of 7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride

There total 10 articles about 7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1261072-34-7
tert-butyl (2S)-2-(4-{4-[6-(2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-4-yl)-3-hydroxyquinoxalin-2-yl]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1261105-97-8
7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 70 ℃; for 4h;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1261105-97-8
7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / dichloromethane / 18 h / 0 - 20 °C

2.1: triethylamine; titanium tetrachloride / dichloromethane / 18 h / 0 - 20 °C

3.1: acetic acid; iron / 4 h / 70 °C

3.2: 2 h / Reflux

4.1: trichlorophosphate / 5 h / 100 °C

5.1: tetrahydrofuran; methanol / 24 h / 20 °C

6.1: potassium carbonate; Trimethylacetic acid / palladium diacetate; tricyclohexylphosphine tetrafluoroborate / ISOPROPYLAMIDE / 16 h / 140 °C

7.1: hydrogenchloride / 1,4-dioxane; ethanol / 4 h / 70 °C

With hydrogenchloride; aluminum (III) chloride; titanium tetrachloride; iron; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; Trimethylacetic acid; palladium diacetate; tricyclohexylphosphine tetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1261105-97-8
7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 1.5 h / 0 °C

1.2: 19 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 20 °C

3.1: potassium carbonate; Trimethylacetic acid / palladium diacetate; tricyclohexylphosphine tetrafluoroborate / ISOPROPYLAMIDE / 16 h / 140 °C

4.1: hydrogenchloride / 1,4-dioxane; ethanol / 4 h / 70 °C

With hydrogenchloride; sodium hypochlorite; sodium hydride; sodium hydrogencarbonate; potassium carbonate; sodium bromide; Trimethylacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; tricyclohexylphosphine tetrafluoroborate; In 1,4-dioxane; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; mineral oil;