methyl {(2S)-1-[(2S)-2-{4-[4-(3-hydroxy-6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}quinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Chemical Name:methyl {(2S)-1-[(2S)-2-{4-[4-(3-hydroxy-6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}quinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate
CAS No.:1261070-40-9
Molecular Formula:C₄₂H₅₀N₁₀O₇
Molecular Weight:806.922
Hs Code.:

methyl {(2S)-1-[(2S)-2-{4-[4-(3-hydroxy-6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}quinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Synonyms:methyl {(2S)-1-[(2S)-2-{4-[4-(3-hydroxy-6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}quinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Chemical Property of methyl {(2S)-1-[(2S)-2-{4-[4-(3-hydroxy-6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}quinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Technology Process of methyl {(2S)-1-[(2S)-2-{4-[4-(3-hydroxy-6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}quinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

There total 12 articles about methyl {(2S)-1-[(2S)-2-{4-[4-(3-hydroxy-6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}quinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1261105-97-8
7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1261070-40-9
methyl {(2S)-1-[(2S)-2-{4-[4-(3-hydroxy-6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}quinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: N-methoxycarbonyl-L-valine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 0.333333h;

7-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-3-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)quinoxalin-2-ol hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 72h;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1261070-40-9
methyl {(2S)-1-[(2S)-2-{4-[4-(3-hydroxy-6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}quinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 1.5 h / 0 °C

1.2: 19 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 20 °C

3.1: potassium carbonate; Trimethylacetic acid / palladium diacetate; tricyclohexylphosphine tetrafluoroborate / ISOPROPYLAMIDE / 16 h / 140 °C

4.1: hydrogenchloride / 1,4-dioxane; ethanol / 4 h / 70 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.33 h / 20 °C

5.2: 72 h / 20 °C

With hydrogenchloride; sodium hypochlorite; sodium hydride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium bromide; Trimethylacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; tricyclohexylphosphine tetrafluoroborate; In 1,4-dioxane; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1261070-40-9
methyl {(2S)-1-[(2S)-2-{4-[4-(3-hydroxy-6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}quinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: aluminum (III) chloride / dichloromethane / 18 h / 0 - 20 °C

2.1: triethylamine; titanium tetrachloride / dichloromethane / 18 h / 0 - 20 °C

3.1: acetic acid; iron / 4 h / 70 °C

3.2: 2 h / Reflux

4.1: trichlorophosphate / 5 h / 100 °C

5.1: tetrahydrofuran; methanol / 24 h / 20 °C

6.1: potassium carbonate; Trimethylacetic acid / palladium diacetate; tricyclohexylphosphine tetrafluoroborate / ISOPROPYLAMIDE / 16 h / 140 °C

7.1: hydrogenchloride / 1,4-dioxane; ethanol / 4 h / 70 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.33 h / 20 °C

8.2: 72 h / 20 °C

With hydrogenchloride; aluminum (III) chloride; titanium tetrachloride; iron; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; Trimethylacetic acid; palladium diacetate; tricyclohexylphosphine tetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; acetonitrile;