(4-methoxy-phenyl)-[5-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-4-yl]-methanone

Base Information

• Chemical Name: (4-methoxy-phenyl)-[5-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-4-yl]-methanone
• CAS No.: 1026591-80-9
• Molecular Formula: C₂₀H₂₀O₆
• Molecular Weight: 356.375
• Mol file: 1026591-80-9.mol

Synonyms:(4-methoxy-phenyl)-[5-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-4-yl]-methanone

Chemical Property of (4-methoxy-phenyl)-[5-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-4-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-methoxy-phenyl)-[5-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-4-yl]-methanone

There total 2 articles about (4-methoxy-phenyl)-[5-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-4-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2-[(3,4-methylenedioxyphenyl)methyl]-1,3-dioxolane (924279-92-5) + 4-methoxy-benzoyl chloride (100-07-2) → (4-methoxy-phenyl)-[5-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-4-yl]-methanone (1026591-80-9)

Guidance literature:

With n-butyllithium; In diethyl ether; hexane; at 0 - 20 ℃; for 5.5h;

DOI:10.1002/jhet.5570430617

Reference yield:

1-(1,3-benzodioxol-5-yl)-2-propanone (4676-39-5) → (4-methoxy-phenyl)-[5-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-4-yl]-methanone (1026591-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / p-toluenesulfonic acid monohydrate / toluene / 12 h / Heating

2: butyl lithium / hexane; diethyl ether / 5.5 h / 0 - 20 °C

With n-butyllithium; toluene-4-sulfonic acid; In diethyl ether; hexane; toluene;

DOI:10.1002/jhet.5570430617

Reference yield: 56.0%

(4-methoxy-phenyl)-[5-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-4-yl]-methanone (1026591-80-9) → 1-[2-(4-methoxybenzoyl)-3,4-methylenedioxyphenyl]propan-2-one (924280-12-6)

Guidance literature:

With sulfuric acid; silica gel; In dichloromethane; water; at 20 ℃; for 5h;

DOI:10.1002/jhet.5570430617

upstream raw materials:

2-methyl-2-[(3,4-methylenedioxyphenyl)methyl]-1,3-dioxolane

4-methoxy-benzoyl chloride

1-(1,3-benzodioxol-5-yl)-2-propanone

Downstream raw materials:

1-[2-(4-methoxybenzoyl)-3,4-methylenedioxyphenyl]propan-2-one