ethyl (2E,2Z)-cyano(4-oxo-3-phenyl-1,3-thiazolidin-2-ylidene)ethanoate

Base Information

• Chemical Name: ethyl (2E,2Z)-cyano(4-oxo-3-phenyl-1,3-thiazolidin-2-ylidene)ethanoate
• CAS No.: 30740-63-7
• Molecular Formula: C₁₄H₁₂N₂O₃S
• Molecular Weight: 288.327
• Mol file: 30740-63-7.mol

Synonyms:ethyl (2E,2Z)-cyano(4-oxo-3-phenyl-1,3-thiazolidin-2-ylidene)ethanoate

Chemical Property of ethyl (2E,2Z)-cyano(4-oxo-3-phenyl-1,3-thiazolidin-2-ylidene)ethanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2E,2Z)-cyano(4-oxo-3-phenyl-1,3-thiazolidin-2-ylidene)ethanoate

There total 4 articles about ethyl (2E,2Z)-cyano(4-oxo-3-phenyl-1,3-thiazolidin-2-ylidene)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

potassium chloroacetate (7748-25-6) + Potassium; (Z)-2-cyano-2-ethoxycarbonyl-1-phenylamino-ethenethiolate → ethyl (2E,2Z)-cyano(4-oxo-3-phenyl-1,3-thiazolidin-2-ylidene)ethanoate (30740-63-7)

Guidance literature:

potassium chloroacetate; Potassium; (Z)-2-cyano-2-ethoxycarbonyl-1-phenylamino-ethenethiolate; In ethanol; water; at 20 ℃; for 1h;

With acetic acid; In ethanol; water; for 0.25h; Reflux;

DOI:10.1007/s10593-019-02568-5

Reference yield:

ethyl 2-cyano-3-(phenylamino)-3-thioxopropanoate (14815-50-0) + ethyl bromoacetate (105-36-2) → ethyl (2E,2Z)-cyano(4-oxo-3-phenyl-1,3-thiazolidin-2-ylidene)ethanoate (30740-63-7)

Guidance literature:

With sodium ethanolate; In ethanol;

DOI:10.1007/BF00522569

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → ethyl (2E,2Z)-cyano(4-oxo-3-phenyl-1,3-thiazolidin-2-ylidene)ethanoate (30740-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 0.5 h / 20 °C

2.1: ethanol; water / 1 h / 20 °C

2.2: 0.25 h / Reflux

With potassium hydroxide; In ethanol; water;

DOI:10.1007/s10593-019-02568-5

upstream raw materials:

ethyl 2-cyano-3-(phenylamino)-3-thioxopropanoate

ethyl bromoacetate

phenyl isothiocyanate

potassium chloroacetate