4-[4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ylidene)-cyclohexylidene]-1-phenylpiperidine

Base Information

Chemical Name:4-[4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ylidene)-cyclohexylidene]-1-phenylpiperidine
CAS No.:623575-26-8
Molecular Formula:C₂₈H₃₉NO₂
Molecular Weight:421.623
Hs Code.:

Synonyms:4-[4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ylidene)-cyclohexylidene]-1-phenylpiperidine

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Chemical Property of 4-[4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ylidene)-cyclohexylidene]-1-phenylpiperidine

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Technology Process of 4-[4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ylidene)-cyclohexylidene]-1-phenylpiperidine

There total 4 articles about 4-[4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ylidene)-cyclohexylidene]-1-phenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 623575-12-2
9-[1-hydroxy-4-(1-phenylpiperidin-4-ylidene)cyclohexyl]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

: 623575-26-8
4-[4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ylidene)-cyclohexylidene]-1-phenylpiperidine

Guidance literature:: With N,N-dimethylformamide dineopentyl acetal; In acetonitrile; Heating;
DOI:10.1021/jp0271716

Reference yield:

: 169822-66-6
3,3-Dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

: 623575-26-8
4-[4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ylidene)-cyclohexylidene]-1-phenylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 2 h / 50 °C

1.2: 47 percent / tetrahydrofuran; hexane / 2 h / 50 °C

2.1: 85 percent / N,N-dimethylformamide dineopentyl acetal / acetonitrile / Heating

With N,N-dimethylformamide dineopentyl acetal; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/jp0271716

Reference yield:

: 193960-10-0
9-(1-Phenylpiperidin-4-ylidene)cyclohexanone

: 623575-26-8
4-[4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ylidene)-cyclohexylidene]-1-phenylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 2 h / 50 °C

1.2: 47 percent / tetrahydrofuran; hexane / 2 h / 50 °C

2.1: 85 percent / N,N-dimethylformamide dineopentyl acetal / acetonitrile / Heating

With N,N-dimethylformamide dineopentyl acetal; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/jp0271716