{(S)-6-[(R)-4-(4-cyano-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

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Chemical Name:{(S)-6-[(R)-4-(4-cyano-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid
CAS No.:1610885-17-0
Molecular Formula:C₂₆H₁₉F₂NO₅
Molecular Weight:463.437
Hs Code.:

Synonyms:{(S)-6-[(R)-4-(4-cyano-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

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Chemical Property of {(S)-6-[(R)-4-(4-cyano-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

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Technology Process of {(S)-6-[(R)-4-(4-cyano-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

There total 9 articles about {(S)-6-[(R)-4-(4-cyano-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3939-09-1,103496-86-2
2,4-difluorobenzonitrile

: 1610884-31-5
{(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

: 1610885-17-0
{(S)-6-[(R)-4-(4-cyano-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

: 1610885-18-1
{(S)-6-[(R)-4-(2-cyano-5-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

Guidance literature:: 2,4-difluorobenzonitrile; {(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester; With caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 0.5h; Microwave irradiation;

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

Reference yield:

: 726174-52-3
(6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester

: 1610885-17-0
{(S)-6-[(R)-4-(4-cyano-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

: 1610885-18-1
{(S)-6-[(R)-4-(2-cyano-5-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 2250.23 Torr

2.1: diethylamine; carbon dioxide / isopropyl alcohol / Resolution of racemate

3.1: di-tert-butyl-diazodicarboxylate; tributylphosphine / tetrahydrofuran / 0.5 h / -10 °C

4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere; Microwave irradiation

5.1: acetic acid; dihydrogen peroxide / water / 2.5 h / 20 °C / Cooling with ice

6.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

6.2: 4 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tributylphosphine; carbon dioxide; di-tert-butyl-diazodicarboxylate; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; potassium acetate; caesium carbonate; acetic acid; diethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 805250-17-3,1234474-58-8
(6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester

: 1610885-17-0
{(S)-6-[(R)-4-(4-cyano-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

: 1610885-18-1
{(S)-6-[(R)-4-(2-cyano-5-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylamine; carbon dioxide / isopropyl alcohol / Resolution of racemate

2.1: di-tert-butyl-diazodicarboxylate; tributylphosphine / tetrahydrofuran / 0.5 h / -10 °C

3.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere; Microwave irradiation

4.1: acetic acid; dihydrogen peroxide / water / 2.5 h / 20 °C / Cooling with ice

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

5.2: 4 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tributylphosphine; carbon dioxide; di-tert-butyl-diazodicarboxylate; dihydrogen peroxide; potassium acetate; caesium carbonate; acetic acid; diethylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol;