3-Benzofuranaceticacid,2,3-dihydro-6-hydroxy-,Methylester

Base Information

• Chemical Name: 3-Benzofuranaceticacid,2,3-dihydro-6-hydroxy-,Methylester
• CAS No.: 805250-17-3
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Hs Code.: 2932999099
• Mol file: 805250-17-3.mol

Synonyms:3-Benzofuranaceticacid,2,3-dihydro-6-hydroxy-,Methylester

Chemical Property of 3-Benzofuranaceticacid,2,3-dihydro-6-hydroxy-,Methylester

Chemical Property:

• Boiling Point: 326.5±42.0℃ (760 Torr)
• PKA: 9.77±0.40(Predicted)
• Flash Point: 126.9±21.4℃
• PSA: 55.76000
• Density: 1.257±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 1.43130
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

(6-Hydroxy-2,3-dihydrobenzofuran-3-yl)aceticAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (6-Hydroxy-2,3-dihydrobenzofuran-3-yl)acetic Acid Methyl Ester was used in the synthetic preparation of TAK-875 (T004915), a novel oral medication that has been developed to improve the secretion of i nsulin in a glucose-dependent manner, which has the potential to improve the control of blood sugar levels without the risk of hypoglycemia. (6-Hydroxy-2,3-dihydrobenzofuran-3-yl)acetic Acid Methyl Ester was used in the synthetic preparation of TAK-875 (T004915), a novel oral medication that has been developed to improve the secretion of insulin in a glucose-dependent manner, which has the potential to improve the control of blood sugar levels without the risk of hypoglycemia.

Technology Process of 3-Benzofuranaceticacid,2,3-dihydro-6-hydroxy-,Methylester

There total 7 articles about 3-Benzofuranaceticacid,2,3-dihydro-6-hydroxy-,Methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

(6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester (726174-52-3) → (6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester (805250-17-3,1234474-58-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 24h;

Reference yield: 93.0%

methanol (67-56-1) + 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetic acid (1000414-37-8) → (6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester (805250-17-3,1234474-58-8)

Guidance literature:

With thionyl chloride; at 20 ℃; for 2.16667h; Cooling with ice;

Reference yield: 24.0%

→ (6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester (805250-17-3,1234474-58-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h;

upstream raw materials:

6-methoxy-3-methoxycarbonylmethyl-2,3-dihydrobenzofuran

(6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester

4-chloromethyl-7-hydroxycoumarin

recorcinol

Downstream raw materials:

{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]-2,3-dihydro-benzofuran-3-yl}acetic acid

methyl {6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]-2,3-dihydro-benzofuran-3-yl}acetate

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