(2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester

Base Information

Chemical Name:(2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester
CAS No.:129786-73-8
Molecular Formula:C₂₃H₂₉NO₆
Molecular Weight:415.486
Hs Code.:

Synonyms:(2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester

Suppliers and Price of (2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester

There total 6 articles about (2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 129786-72-7
<4R-(R*,S*)>-2,2-dimethyl-4-<(phenylmethoxy)<(phenylmethoxy)carbonyl>methyl>-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester

: 129786-73-8
(2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester

Guidance literature:: With water; toluene-4-sulfonic acid; In methanol; for 18h; Heating;
DOI:10.1021/jo00313a015

Reference yield:

: 100-39-0
benzyl bromide

: 129786-73-8
(2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaH (50percent in mineral oil) / dimethylformamide / 2 h / Ambient temperature

2: H₂O / dimethylformamide / 0.75 h / Ambient temperature

3: NaIO₄, RuCl₃*H₂O, H₂O / acetonitrile; CCl₄ / 1 h / Ambient temperature

4: K₂CO₃ / dimethylformamide / 16 h

5: 73 percent / H₂O, p-toluenesulfonic acid monohydrate / methanol / 18 h / Heating

With ruthenium trichloride; sodium periodate; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00313a015

Reference yield:

: 129786-70-5
(4R)-4-((1R)-1-hydroxy-3-trimethylsilanyl-prop-2-ynyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 129786-73-8
(2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaH (50percent in mineral oil) / dimethylformamide / 2 h / Ambient temperature

2: H₂O / dimethylformamide / 0.75 h / Ambient temperature

3: NaIO₄, RuCl₃*H₂O, H₂O / acetonitrile; CCl₄ / 1 h / Ambient temperature

4: K₂CO₃ / dimethylformamide / 16 h

5: 73 percent / H₂O, p-toluenesulfonic acid monohydrate / methanol / 18 h / Heating

With ruthenium trichloride; sodium periodate; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00313a015