methyl 1,6-dihydro-5-methoxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate

Base Information

• Chemical Name: methyl 1,6-dihydro-5-methoxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate
• CAS No.: 1394136-32-3
• Molecular Formula: C₁₄H₁₀F₄N₂O₄
• Molecular Weight: 346.238

Synonyms:methyl 1,6-dihydro-5-methoxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate

Chemical Property of methyl 1,6-dihydro-5-methoxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate

Chemical Property:

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Technology Process of methyl 1,6-dihydro-5-methoxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate

There total 3 articles about methyl 1,6-dihydro-5-methoxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate (1394136-29-8) + methyl iodide (74-88-4) → methyl 1,6-dihydro-5-methoxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate (1394136-32-3)

Guidance literature:

methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate; With potassium carbonate; In acetone; for 0.5h;

methyl iodide; In acetone; for 36h; Reflux;

DOI:10.1016/j.ejmech.2012.04.020

Reference yield:

dimethyl 2-<(1-methylethyl)amino>-3-(trifluoroacetyl)-2-butenedioate → methyl 1,6-dihydro-5-methoxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate (1394136-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diethyl ether / 10 h

2.1: hydrogenchloride / water / 1 h / 0 °C / pH 2 - 3

3.1: potassium carbonate / acetone / 0.5 h

3.2: 36 h / Reflux

With hydrogenchloride; potassium carbonate; In diethyl ether; water; acetone;

DOI:10.1016/j.ejmech.2012.04.020

Reference yield:

4-fluorophenylhydrazine (371-14-2) → methyl 1,6-dihydro-5-methoxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate (1394136-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diethyl ether / 10 h

2.1: hydrogenchloride / water / 1 h / 0 °C / pH 2 - 3

3.1: potassium carbonate / acetone / 0.5 h

3.2: 36 h / Reflux

With hydrogenchloride; potassium carbonate; In diethyl ether; water; acetone;

DOI:10.1016/j.ejmech.2012.04.020

upstream raw materials:

methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate

methyl iodide

4-fluorophenylhydrazine

Downstream raw materials:

N-(4-fluorobenzyl)-1-(4-fluorophenyl)-5-hydroxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxamide

N-(4-fluorobenzyl)-5-(4-fluorobenzylamino)-1-(4-fluorophenyl)-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxamide

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