N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Base Information

Chemical Name:N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide
CAS No.:1616235-95-0
Molecular Formula:C₂₃H₁₈FN₇O
Molecular Weight:427.441
Hs Code.:

Synonyms:N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

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Chemical Property of N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

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Technology Process of N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

There total 6 articles about N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1162680-90-1
N-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

: 1616235-93-8
4-(4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)pyridine

: 1616235-95-0
N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1616235-79-0
3,3-dibromo-1-(4-fluorophenyl)prop-2-en-1-one

: 1616235-95-0
N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 16 h / 20 °C / Molecular sieve

2: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

3: N-Bromosuccinimide / dichloromethane / 0 - 20 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1188146-14-6
5-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

: 1616235-95-0
N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

2: N-Bromosuccinimide / dichloromethane / 0 - 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;