diethyl 4-[3-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:diethyl 4-[3-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:1346239-52-8
Molecular Formula:C₂₂H₂₃Cl₂N₃O₄
Molecular Weight:464.348
Hs Code.:

Synonyms:diethyl 4-[3-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of diethyl 4-[3-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of diethyl 4-[3-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 3 articles about diethyl 4-[3-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1031794-72-5
3-(2,4-dichlorophenyl)-1H-pyrazole-4-carbaldehyde

: 141-97-9
ethyl acetoacetate

: 1346239-52-8
diethyl 4-[3-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With ammonium acetate; In ethanol; for 8h; Reflux;
DOI:10.1016/j.ejmech.2011.09.026

Reference yield:

: 1-(2,4-dichloro-phenyl)-ethanone semicarbazone

: 1346239-52-8
diethyl 4-[3-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 6.5 h / 65 °C / Cooling with ice

1.2: pH 7 / Cooling with ice

2.1: ammonium acetate / ethanol / 8 h / Reflux

With ammonium acetate; trichlorophosphate; In ethanol; 1.1: Vilsmeier-Haack reaction / 2.1: Hantzsch pyridine synthesis;
DOI:10.1016/j.ejmech.2011.09.026

Reference yield:

: 2234-16-4
1-(2,4-dichlorophenyl)ethan-1-one

: 1346239-52-8
diethyl 4-[3-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate / ethanol / 8 h / 80 °C

2.1: trichlorophosphate / 6.5 h / 65 °C / Cooling with ice

2.2: pH 7 / Cooling with ice

3.1: ammonium acetate / ethanol / 8 h / Reflux

With ammonium acetate; sodium acetate; trichlorophosphate; In ethanol; 2.1: Vilsmeier-Haack reaction / 3.1: Hantzsch pyridine synthesis;
DOI:10.1016/j.ejmech.2011.09.026