trans-(4R,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one

Base Information

Chemical Name:trans-(4R,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one
CAS No.:1324004-29-6
Molecular Formula:C₃₃H₄₁N₃O₂
Molecular Weight:511.707
Hs Code.:

Synonyms:trans-(4R,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one

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Chemical Property of trans-(4R,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one

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Technology Process of trans-(4R,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one

There total 5 articles about trans-(4R,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

: 1324003-93-1
(S)-1-benzyl-3-phenyl-1-(1-phenylbut-3-en-2-yl)urea

: 1324004-32-1
cis-(4S,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one

: 1324004-29-6
trans-(4R,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one

Guidance literature:: With 2-(2-(4,5-dihydrooxazol-2-yl)propan-2-yl)-4,5-dihydrooxazole; oxygen; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; In α,α,α-trifluorotoluene; at 120 ℃; for 24h; under 760.051 Torr; optical yield given as %de; diastereoselective reaction;
DOI:10.1002/ejoc.201100444

Reference yield:

: C₁₇H₁₇N

: 1324004-32-1
cis-(4S,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one

: 1324004-29-6
trans-(4R,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 20 °C

2: dichloromethane / 2 h / 20 °C

3: 2-(2-(4,5-dihydrooxazol-2-yl)propan-2-yl)-4,5-dihydrooxazole; oxygen; copper(II) bis(trifluoromethanesulfonate); potassium carbonate / α,α,α-trifluorotoluene / 24 h / 120 °C / 760.05 Torr

With sodium tetrahydroborate; 2-(2-(4,5-dihydrooxazol-2-yl)propan-2-yl)-4,5-dihydrooxazole; oxygen; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; In methanol; dichloromethane; α,α,α-trifluorotoluene;
DOI:10.1002/ejoc.201100444

Reference yield:

: 126410-30-8
(S)-1-phenylbut-3-en-2-amine

: 1324004-32-1
cis-(4S,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one

: 1324004-29-6
trans-(4R,5S)-1,5-dibenzyl-3-phenyl-4-((2,2,6,6-tetramethylpiperidin-1-yloxy)methyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / methanol / 0.33 h / 20 °C

2: sodium tetrahydroborate / methanol / 20 °C

3: dichloromethane / 2 h / 20 °C

4: 2-(2-(4,5-dihydrooxazol-2-yl)propan-2-yl)-4,5-dihydrooxazole; oxygen; copper(II) bis(trifluoromethanesulfonate); potassium carbonate / α,α,α-trifluorotoluene / 24 h / 120 °C / 760.05 Torr

With sodium tetrahydroborate; 2-(2-(4,5-dihydrooxazol-2-yl)propan-2-yl)-4,5-dihydrooxazole; oxygen; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; triethylamine; In methanol; dichloromethane; α,α,α-trifluorotoluene;
DOI:10.1002/ejoc.201100444