2-(3-chloro-4-(methylsulfonyl)phenyl)-3-(8,8-dimethyl-6,10-dioxaspiro[4.5]-decan-2(R)-yl)propanoic acid

Base Information

Chemical Name:2-(3-chloro-4-(methylsulfonyl)phenyl)-3-(8,8-dimethyl-6,10-dioxaspiro[4.5]-decan-2(R)-yl)propanoic acid
CAS No.:952517-42-9
Molecular Formula:C₂₀H₂₇ClO₆S
Molecular Weight:430.95
Hs Code.:

Synonyms:2-(3-chloro-4-(methylsulfonyl)phenyl)-3-(8,8-dimethyl-6,10-dioxaspiro[4.5]-decan-2(R)-yl)propanoic acid

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Chemical Property of 2-(3-chloro-4-(methylsulfonyl)phenyl)-3-(8,8-dimethyl-6,10-dioxaspiro[4.5]-decan-2(R)-yl)propanoic acid

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Technology Process of 2-(3-chloro-4-(methylsulfonyl)phenyl)-3-(8,8-dimethyl-6,10-dioxaspiro[4.5]-decan-2(R)-yl)propanoic acid

There total 3 articles about 2-(3-chloro-4-(methylsulfonyl)phenyl)-3-(8,8-dimethyl-6,10-dioxaspiro[4.5]-decan-2(R)-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

: 952517-41-8
C₂₀H₂₇ClO₄S

: 952517-42-9
2-(3-chloro-4-(methylsulfonyl)phenyl)-3-(8,8-dimethyl-6,10-dioxaspiro[4.5]-decan-2(R)-yl)propanoic acid

Guidance literature:: With sodium tungstate; dihydrogen peroxide; potassium hydrogencarbonate; acetic acid; In water; acetone; at 30 ℃; for 37.5h; pH=7.1 - 8;

Reference yield: 73.8%

: 300355-14-0
(3-chloro-4-methylsulfanylphenyl)acetic acid ethyl ester

: 1036233-14-3
(S)-(8,8-dimethyl-6,10-dioxaspiro[4.5]decan-2-yl)methyl 4-methylbenzenesulfonate

: 952517-42-9
2-(3-chloro-4-(methylsulfonyl)phenyl)-3-(8,8-dimethyl-6,10-dioxaspiro[4.5]-decan-2(R)-yl)propanoic acid

Guidance literature:: (3-chloro-4-methylsulfanylphenyl)acetic acid ethyl ester; With potassium tert-butylate; In tetrahydrofuran; at -15 ℃; for 2h;

(S)-(8,8-dimethyl-6,10-dioxaspiro[4.5]decan-2-yl)methyl 4-methylbenzenesulfonate; In tetrahydrofuran; at 0 - 40 ℃;

With sodium hydroxide; sodium tungstate; dihydrogen peroxide; sodium hydrogencarbonate; more than 3 stages;

Reference yield:

: 952517-43-0
C₈H₁₁N*C₂₀H₂₇ClO₆S

: 952517-42-9
2-(3-chloro-4-(methylsulfonyl)phenyl)-3-(8,8-dimethyl-6,10-dioxaspiro[4.5]-decan-2(R)-yl)propanoic acid

Guidance literature:: C₈H₁₁N*C₂₀H₂₇ClO₆S; With citric acid; In water; ethyl acetate;

With sodium hydrogencarbonate; In water; ethyl acetate; Product distribution / selectivity;