(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid

Base Information

Chemical Name:(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid
CAS No.:1260170-82-8
Molecular Formula:C₁₈H₂₅N₃O₇S₂
Molecular Weight:459.544
Hs Code.:

Synonyms:(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid

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Chemical Property of (S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid

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Technology Process of (S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid

There total 7 articles about (S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1260170-81-7
methyl (S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoate

: 1260170-82-8
(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid

Guidance literature:: methyl (S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoate; With water; lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 20h;

With acetic acid; In water; pH=6;

Reference yield:

: 4-but-2-ynyloxy-benzenesulfonic acid sodium salt

: 1260170-82-8
(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 18 h / -10 - 20 °C

2.1: triethylamine / dichloromethane / 18 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 0 - 20 °C

3.2: pH 6

With oxalyl dichloride; water; triethylamine; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 825-90-1
sodium p-hydroxybenzenesulfonate

: 1260170-82-8
(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / isopropyl alcohol; water / 18 h / 70 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 18 h / -10 - 20 °C

3.1: triethylamine / dichloromethane / 18 h / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 0 - 20 °C

4.2: pH 6

With oxalyl dichloride; water; triethylamine; sodium hydroxide; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol;