(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-N-hydroxy-2-(4-methanesulfonylpiperazin-1-yl)propionamide

Base Information

Chemical Name:(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-N-hydroxy-2-(4-methanesulfonylpiperazin-1-yl)propionamide
CAS No.:1260170-78-2
Molecular Formula:C₁₈H₂₆N₄O₇S₂
Molecular Weight:474.559
Hs Code.:

Synonyms:(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-N-hydroxy-2-(4-methanesulfonylpiperazin-1-yl)propionamide

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Chemical Property of (S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-N-hydroxy-2-(4-methanesulfonylpiperazin-1-yl)propionamide

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Technology Process of (S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-N-hydroxy-2-(4-methanesulfonylpiperazin-1-yl)propionamide

There total 8 articles about (S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-N-hydroxy-2-(4-methanesulfonylpiperazin-1-yl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1260170-82-8
(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid

: 1260170-78-2
(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-N-hydroxy-2-(4-methanesulfonylpiperazin-1-yl)propionamide

Guidance literature:: (S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.5h;

With O-(tert-butyldimethylsilanyl)hydroxylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

With water; citric acid; In N,N-dimethyl-formamide; for 0.5h;

Reference yield:

: 4-but-2-ynyloxy-benzenesulfonic acid sodium salt

: 1260170-78-2
(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-N-hydroxy-2-(4-methanesulfonylpiperazin-1-yl)propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 18 h / -10 - 20 °C

2.1: triethylamine / dichloromethane / 18 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 0 - 20 °C

3.2: pH 6

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

4.2: 20 h / 20 °C

4.3: 0.5 h

With oxalyl dichloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 825-90-1
sodium p-hydroxybenzenesulfonate

: 1260170-78-2
(S)-3-(4-but-2-ynyloxybenzenesulfonylamino)-N-hydroxy-2-(4-methanesulfonylpiperazin-1-yl)propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / isopropyl alcohol; water / 18 h / 70 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 18 h / -10 - 20 °C

3.1: triethylamine / dichloromethane / 18 h / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 0 - 20 °C

4.2: pH 6

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

5.2: 20 h / 20 °C

5.3: 0.5 h

With oxalyl dichloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;