(S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione

Base Information

Chemical Name:(S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione
CAS No.:349490-14-8
Molecular Formula:C₁₆H₂₀N₂O₅Se
Molecular Weight:399.305
Hs Code.:

Synonyms:(S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione

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Chemical Property of (S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione

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Technology Process of (S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione

There total 2 articles about (S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 349490-12-6
(S)-1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione

: 349490-14-8
(S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione

Guidance literature:: With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; for 12h;
DOI:10.1021/ja010180s

Reference yield:

: 208466-63-1
1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione

: 349490-14-8
(S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 0.081 g / TFA / tetrahydrofuran; H₂O / 4 h / 0 °C

2: 88 percent / Et₃N*3HF / tetrahydrofuran / 12 h

With triethylamine tris(hydrogen fluoride); trifluoroacetic acid; In tetrahydrofuran; water;
DOI:10.1021/ja010180s

Reference yield: 58.0%

: 109389-30-2
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

: 349490-14-8
(S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione

: 349490-16-0
C₄₉H₅₂N₅O₁₄PSe

Guidance literature:: Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester; (S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylselanyl-dihydro-pyrimidine-2,4-dione; With 1H-tetrazole; In tetrahydrofuran; acetonitrile; at 0 ℃; for 4h;

With 2,6-dimethylpyridine; water; iodine; In tetrahydrofuran; Further stages.;
DOI:10.1021/ja010180s