tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate

Base Information

Chemical Name:tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate
CAS No.:1622180-56-6
Molecular Formula:C₁₉H₂₅NO₄
Molecular Weight:331.412
Hs Code.:

Synonyms:tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate

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Chemical Property of tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate

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Technology Process of tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate

There total 12 articles about tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1622180-53-3
(5R,7S)-7-(4-bromophenyl)-3-oxa-1-azaspiro[4.4]nonan-2-one

: 1622180-56-6
tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate

Guidance literature:: (5R,7S)-7-(4-bromophenyl)-3-oxa-1-azaspiro[4.4]nonan-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 0.5h; Inert atmosphere;

(2-(tert-butoxy)-2-oxoethyl)zinc(II) halide; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; In tetrahydrofuran; 1,4-dioxane; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b01695

Reference yield:

: 321745-86-2
2-tert-butoxy-2-oxoethylzinc chloride

: 1622180-53-3
(5R,7S)-7-(4-bromophenyl)-3-oxa-1-azaspiro[4.4]nonan-2-one

: 1622180-56-6
tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate

Guidance literature:: (5R,7S)-7-(4-bromophenyl)-3-oxa-1-azaspiro[4.4]nonan-2-one; With lithium hexamethyldisilazane; In 1,4-dioxane; at 20 ℃; for 0.5h;

2-tert-butoxy-2-oxoethylzinc chloride; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; In 1,4-dioxane; at 80 ℃; for 2h;

Reference yield:

: 1240554-98-6
((1R,3S)-1-amino-3-(4-bromophenyl)cyclopentyl)methanol

: 1622180-56-6
tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 1,4-dioxane / 4 h

2.1: lithium hexamethyldisilazane / 1,4-dioxane / 0.5 h / 20 °C

2.2: 2 h / 80 °C

With pyridine; lithium hexamethyldisilazane; In 1,4-dioxane;