5-[(4-hydroxyphenyl)methyl]-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6-one

Base Information

Chemical Name:5-[(4-hydroxyphenyl)methyl]-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6-one
CAS No.:1448820-03-8
Molecular Formula:C₁₁H₁₃N₃O₂
Molecular Weight:219.243
Hs Code.:

Synonyms:5-[(4-hydroxyphenyl)methyl]-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[(4-hydroxyphenyl)methyl]-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6-one

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Technology Process of 5-[(4-hydroxyphenyl)methyl]-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6-one

There total 6 articles about 5-[(4-hydroxyphenyl)methyl]-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 7662-51-3
L-tyrosine hydrazide

: 78-39-7
Triethyl orthoacetate

: 1448820-03-8
5-[(4-hydroxyphenyl)methyl]-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6-one

Guidance literature:: With toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene; for 6h; Reflux;
DOI:10.1016/j.tetlet.2013.06.052

Reference yield: 55.0%

: 7662-51-3
L-tyrosine hydrazide

: 78-39-7
Triethyl orthoacetate

: 1-[(1-ethoxyethylene)amino]-2-methyl-4-(4-hydroxybenzyl)imidazol-5(4H)-one

: 1448820-03-8
5-[(4-hydroxyphenyl)methyl]-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6-one

Guidance literature:: With toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene;
DOI:10.1016/j.tetlet.2013.06.052

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 1448820-03-8
5-[(4-hydroxyphenyl)methyl]-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 24 h / 20 °C

2: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux

With toluene-4-sulfonic acid; hydrazine hydrate; In methanol; 5,5-dimethyl-1,3-cyclohexadiene;
DOI:10.1016/j.tetlet.2013.06.052