2,3-bis[[N-[11-(2-hydroxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene

Base Information

• Chemical Name: 2,3-bis[[N-[11-(2-hydroxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene
• CAS No.: 382162-22-3
• Molecular Formula: C₄₂H₅₆N₂O₁₈
• Molecular Weight: 876.909
• Mol file: 382162-22-3.mol

Synonyms:2,3-bis[[N-[11-(2-hydroxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene

Chemical Property of 2,3-bis[[N-[11-(2-hydroxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-bis[[N-[11-(2-hydroxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene

There total 17 articles about 2,3-bis[[N-[11-(2-hydroxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2,3-bis[[N-[11-(2-allyloxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene (382162-19-8) → 2,3-bis[[N-[11-(2-hydroxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene (382162-22-3)

Guidance literature:

With triethylammonium formate; triphenylphosphine; palladium diacetate; In ethanol; water; for 1.5h; pH=8; Heating;

DOI:10.1039/b103274g

Reference yield:

Tetraethylene glycol (112-60-7) → 2,3-bis[[N-[11-(2-hydroxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene (382162-22-3)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 28 g / triethylamine; DMAP / CH₂Cl₂ / 10 h / 20 °C

2.1: 84 percent / dimethylformamide / 8 h / 100 °C

3.1: 64 percent / triethylamine; DMAP / CH₂Cl₂ / 6 h / 20 °C

4.1: 83 percent / K₂CO₃ / acetonitrile / 48 h / Heating

5.1: 100 percent / trimethyl orthoformate; toluene-p-sulfonic acid / toluene / 8 h / Heating

6.1: 79 percent / N₂H₄*H₂O / methanol / 5 h / Heating

7.1: 74 percent / triethylamine; DMAP / CH₂Cl₂ / 18 h / 0 - 20 °C

8.1: LiAlH₄ / tetrahydrofuran / 4 h / 0 - 20 °C

8.2: 99 percent / aq. HCl / tetrahydrofuran / pH 1

9.1: 62 percent / triethylammonium formate; triphenylphosphine / Pd(CH₃COO)2 / ethanol; H₂O / 1.5 h / pH 8 / Heating

With dmap; lithium aluminium tetrahydride; triethylammonium formate; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; triphenylphosphine; trimethyl orthoformate; palladium diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1039/b103274g

Reference yield:

2,3-dihydroxybenzaldehyde (24677-78-9) → 2,3-bis[[N-[11-(2-hydroxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene (382162-22-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 50 percent / NaH / dimethylsulfoxide / 20 °C

2.1: 83 percent / K₂CO₃ / acetonitrile / 48 h / Heating

3.1: 100 percent / trimethyl orthoformate; toluene-p-sulfonic acid / toluene / 8 h / Heating

4.1: 79 percent / N₂H₄*H₂O / methanol / 5 h / Heating

5.1: 74 percent / triethylamine; DMAP / CH₂Cl₂ / 18 h / 0 - 20 °C

6.1: LiAlH₄ / tetrahydrofuran / 4 h / 0 - 20 °C

6.2: 99 percent / aq. HCl / tetrahydrofuran / pH 1

7.1: 62 percent / triethylammonium formate; triphenylphosphine / Pd(CH₃COO)2 / ethanol; H₂O / 1.5 h / pH 8 / Heating

With dmap; lithium aluminium tetrahydride; sodium hydride; triethylammonium formate; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; triphenylphosphine; trimethyl orthoformate; palladium diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;

DOI:10.1039/b103274g

upstream raw materials:

2,3-bis[[N-[11-(2-allyloxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene

Tetraethylene glycol

2,3-dihydroxybenzaldehyde

dimethyl 2,3-dihydroxyterephthalate