tert-butyl 3-(bis(2,2,2-trifluoroethoxy)phosphoryl)-2-oxopropylcarbamate

Base Information

Chemical Name:tert-butyl 3-(bis(2,2,2-trifluoroethoxy)phosphoryl)-2-oxopropylcarbamate
CAS No.:1383610-28-3
Molecular Formula:C₁₂H₁₈F₆NO₆P
Molecular Weight:417.242
Hs Code.:

Synonyms:tert-butyl 3-(bis(2,2,2-trifluoroethoxy)phosphoryl)-2-oxopropylcarbamate

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Chemical Property of tert-butyl 3-(bis(2,2,2-trifluoroethoxy)phosphoryl)-2-oxopropylcarbamate

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Technology Process of tert-butyl 3-(bis(2,2,2-trifluoroethoxy)phosphoryl)-2-oxopropylcarbamate

There total 1 articles about tert-butyl 3-(bis(2,2,2-trifluoroethoxy)phosphoryl)-2-oxopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 31954-27-5
N-(tert-butoxycarbonyl)glycine methyl ester

: 757-95-9
bis(2,2,2-trifluoroethyl)(methyl)phosphonate

: 1383610-28-3
tert-butyl 3-(bis(2,2,2-trifluoroethoxy)phosphoryl)-2-oxopropylcarbamate

Guidance literature:: bis(2,2,2-trifluoroethyl)(methyl)phosphonate; With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane; In tetrahydrofuran; at -98 ℃; for 0.25h; Inert atmosphere;

N-(tert-butoxycarbonyl)glycine methyl ester; In tetrahydrofuran; at -98 ℃; for 1.66667h; Inert atmosphere;
DOI:10.1016/j.tet.2012.04.082

Reference yield:

: 1383610-28-3
tert-butyl 3-(bis(2,2,2-trifluoroethoxy)phosphoryl)-2-oxopropylcarbamate

: 1383610-35-2
(2S)-4-oxobutan-2-yl 2-[(1E)-3-[(tert-butyldimethylsilyl)oxy]-3-oxoprop-1-en-1-yl]-4-methoxy-6-(methoxymethoxy)benzoate

: C₂₃H₂₉NO₉

: 1383610-38-5
(2E)-3-[2-({[(2S,4E)-7-{[(tert-butoxy)carbonyl]amino}-6-oxohept-4-en-2-yl]oxy}carbonyl)-5-methoxy-3-(methoxymethoxy)phenyl]prop-2-enoic acid

Guidance literature:: tert-butyl 3-(bis(2,2,2-trifluoroethoxy)phosphoryl)-2-oxopropylcarbamate; With potassium carbonate; In tetrahydrofuran; at -10 ℃; for 0.333333h; Inert atmosphere;

(2S)-4-oxobutan-2-yl 2-[(1E)-3-[(tert-butyldimethylsilyl)oxy]-3-oxoprop-1-en-1-yl]-4-methoxy-6-(methoxymethoxy)benzoate; In tetrahydrofuran; at -10 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; stereoselective reaction;
DOI:10.1016/j.tet.2012.04.082