L-2-(5-hydroxymethyl-8-methyl-3,4-dihydropyrido[4,3-e]-1,3-oxazin-3-yl)phenylalaninamide

Base Information

• Chemical Name: L-2-(5-hydroxymethyl-8-methyl-3,4-dihydropyrido[4,3-e]-1,3-oxazin-3-yl)phenylalaninamide
• CAS No.: 739364-86-4
• Molecular Formula: C₁₈H₂₁N₃O₃
• Molecular Weight: 327.383
• Mol file: 739364-86-4.mol

Synonyms:L-2-(5-hydroxymethyl-8-methyl-3,4-dihydropyrido[4,3-e]-1,3-oxazin-3-yl)phenylalaninamide

Chemical Property of L-2-(5-hydroxymethyl-8-methyl-3,4-dihydropyrido[4,3-e]-1,3-oxazin-3-yl)phenylalaninamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-2-(5-hydroxymethyl-8-methyl-3,4-dihydropyrido[4,3-e]-1,3-oxazin-3-yl)phenylalaninamide

There total 2 articles about L-2-(5-hydroxymethyl-8-methyl-3,4-dihydropyrido[4,3-e]-1,3-oxazin-3-yl)phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + L-2-(3-hydroxy-5-hydroxymethyl-2-methylpyridin-4-ylmethyl)amino-N-phenylalaninamide (739364-85-3) → L-2-(5-hydroxymethyl-8-methyl-3,4-dihydropyrido[4,3-e]-1,3-oxazin-3-yl)phenylalaninamide (739364-86-4)

Guidance literature:

With potassium hydroxide; In methanol; for 2h; Heating;

DOI:10.1021/ja039622l

Reference yield:

L-Phenylalanine amide (5241-58-7) → L-2-(5-hydroxymethyl-8-methyl-3,4-dihydropyrido[4,3-e]-1,3-oxazin-3-yl)phenylalaninamide (739364-86-4)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 0.5 h / 20 °C

2: NaBH₄ / methanol / 0 - 20 °C

3: 56 percent / KOH / methanol / 2 h / Heating

With potassium hydroxide; sodium tetrahydroborate; In methanol;

DOI:10.1021/ja039622l

upstream raw materials:

formaldehyd

L-2-(3-hydroxy-5-hydroxymethyl-2-methylpyridin-4-ylmethyl)amino-N-phenylalaninamide

L-Phenylalanine amide