(2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine

Base Information

Chemical Name:(2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine
CAS No.:223394-25-0
Molecular Formula:C₁₇H₂₃NO₅
Molecular Weight:321.373
Hs Code.:

Synonyms:(2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine

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Technology Process of (2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine

There total 1 articles about (2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 10601-80-6
ethyl 3,3-diethoxypropanoate

: (1R,2S)-N-ethoxycarbonyl norephedrine

: 223394-25-0
(2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine

Guidance literature:: With boron trifluoride diethyl etherate; In benzene; Ambient temperature;
DOI:10.1016/S0040-4020(99)00046-0

Reference yield: 100.0%

: 223394-25-0
(2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine

: (4S,5R)-N-(2'-ethoxycarbonylethenyl)-5-phenyl-4-methyl-oxazolidinone

Guidance literature:: With tert-butyl formate; tert.-butyl lithium; pivalaldehyde; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/S0040-4020(99)00046-0

Reference yield:

: 223394-25-0
(2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine

: 223394-32-9
(1R,2S,5R,6R)-3-aza-1-phenyl-6-furyl-5-hydroxymethyl-2,3-dimethyl-1,6-hexanediol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) tBuLi, HCO₂tBu / 1.) THF, -78 deg C, 15 min, 2.) THF, 20 deg C, 25 min

2: 80 percent / LiAlH₄, AlCl₃ / tetrahydrofuran / 0.25 h / 0 °C

With lithium aluminium tetrahydride; aluminium trichloride; tert-butyl formate; tert.-butyl lithium; In tetrahydrofuran;
DOI:10.1016/S0040-4020(99)00046-0