6-(2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl)indolin-2-one

Base Information

Chemical Name:6-(2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl)indolin-2-one
CAS No.:1360907-14-7
Molecular Formula:C₂₄H₂₀N₂O₅
Molecular Weight:416.433
Hs Code.:

Synonyms:6-(2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl)indolin-2-one

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Chemical Property of 6-(2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl)indolin-2-one

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Technology Process of 6-(2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl)indolin-2-one

There total 6 articles about 6-(2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1360904-14-8
7-chloro-2-(3,4,5-trimethoxy-phenyl)furo[3,2-b]pyridine

: 1360911-47-2
2-hydroxy-1,1,2-trimethylpropyl hydrogen (2-oxo-2,3-dihydro-1H-indol-6-yl)boronate

: 1360907-14-7
6-(2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl)indolin-2-one

Guidance literature:: With caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; water; at 100 ℃; for 12h; Sealed tube;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1360907-14-7
6-(2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl)indolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 0.08 h / Inert atmosphere

1.2: 18 h / 500 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

3.1: trichlorophosphate / 2 h / 100 °C / Sealed tube

4.1: potassium fluoride; N-iodo-succinimide / acetonitrile / 2 h / 20 - 50 °C / Inert atmosphere

5.1: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 0.75 h / 150 °C / Microwave irradiation

6.1: caesium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 12 h / 100 °C / Sealed tube

With potassium fluoride; N-iodo-succinimide; copper(l) iodide; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; In 1,4-dioxane; dichloromethane; water; acetonitrile; 5.1: Suzuki Coupling / 6.1: Suzuki Coupling;

Reference yield:

: 111079-44-8
2-trimethylsilylfuro<3,2-b>pyridine

: 1360907-14-7
6-(2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl)indolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

2: trichlorophosphate / 2 h / 100 °C / Sealed tube

3: potassium fluoride; N-iodo-succinimide / acetonitrile / 2 h / 20 - 50 °C / Inert atmosphere

4: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 0.75 h / 150 °C / Microwave irradiation

5: caesium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 12 h / 100 °C / Sealed tube

With potassium fluoride; N-iodo-succinimide; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; dichloromethane; water; acetonitrile; 4: Suzuki Coupling / 5: Suzuki Coupling;