9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-(tritylamino)pentyl]carbamate

Base Information

• Chemical Name: 9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-(tritylamino)pentyl]carbamate
• CAS No.: 1596360-18-7
• Molecular Formula: C₄₀H₃₇N₃O₂
• Molecular Weight: 591.753
• Mol file: 1596360-18-7.mol

Synonyms:9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-(tritylamino)pentyl]carbamate

Chemical Property of 9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-(tritylamino)pentyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-(tritylamino)pentyl]carbamate

There total 2 articles about 9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-(tritylamino)pentyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9H-fluoren-9-ylmethyl N-[(5S)-6-amino-6-oxo-5-(tritylamino)hexyl]carbamate (1596360-17-6) → 9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-(tritylamino)pentyl]carbamate (1596360-18-7)

Guidance literature:

With ammonium chloride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; for 0.0833333h; Cooling;

DOI:10.1016/j.bmc.2014.02.002

Reference yield:

(S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride (253138-02-2,367272-52-4) + trityl chloride (76-83-5) → 9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-(tritylamino)pentyl]carbamate (1596360-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 6 h / 20 °C / Cooling

2: triethylamine; ammonium chloride; trifluoroacetic anhydride / tetrahydrofuran / 0.08 h / Cooling

With ammonium chloride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2014.02.002

upstream raw materials:

(S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride

trityl chloride

9H-fluoren-9-ylmethyl N-[(5S)-6-amino-6-oxo-5-(tritylamino)hexyl]carbamate