ethyl 2-diazo-2-{[1'-(tert-butylsulfonyl)amino]-2'-phenylcyclohexyl}acetate

Base Information

Chemical Name:ethyl 2-diazo-2-{[1'-(tert-butylsulfonyl)amino]-2'-phenylcyclohexyl}acetate
CAS No.:899440-35-8
Molecular Formula:C₂₀H₂₉N₃O₄S
Molecular Weight:407.534
Hs Code.:

Synonyms:ethyl 2-diazo-2-{[1'-(tert-butylsulfonyl)amino]-2'-phenylcyclohexyl}acetate

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Chemical Property of ethyl 2-diazo-2-{[1'-(tert-butylsulfonyl)amino]-2'-phenylcyclohexyl}acetate

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Technology Process of ethyl 2-diazo-2-{[1'-(tert-butylsulfonyl)amino]-2'-phenylcyclohexyl}acetate

There total 3 articles about ethyl 2-diazo-2-{[1'-(tert-butylsulfonyl)amino]-2'-phenylcyclohexyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: N-2-phenylcyclohexylidine-tert-butanesulfonamide

: 623-73-4
diazoacetic acid ethyl ester

: 899440-35-8
ethyl 2-diazo-2-{[1'-(tert-butylsulfonyl)amino]-2'-phenylcyclohexyl}acetate

Guidance literature:: diazoacetic acid ethyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

N-2-phenylcyclohexylidine-tert-butanesulfonamide; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; hexane; at -78 ℃; for 8h;
DOI:10.1055/s-2006-926449

Reference yield:

: 899440-23-4
2-methyl-propane-2-sulfinic acid (2-phenyl-cyclohexylidene)-amide

: 899440-35-8
ethyl 2-diazo-2-{[1'-(tert-butylsulfonyl)amino]-2'-phenylcyclohexyl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / MCPBA / CH₂Cl₂ / 0.5 h / 20 °C

2.1: i-Pr₂NH; n-BuLi / tetrahydrofuran; hexane / 0.08 h / -78 °C

2.2: 62 percent / HMPA / tetrahydrofuran; hexane / 8 h / -78 °C

With n-butyllithium; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-2006-926449

Reference yield:

: 1444-65-1
(RS)-2-phenylcyclohexanone

: 899440-35-8
ethyl 2-diazo-2-{[1'-(tert-butylsulfonyl)amino]-2'-phenylcyclohexyl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 61 percent / Ti(OEt)4 / tetrahydrofuran / 6 h / Heating

2.1: 83 percent / MCPBA / CH₂Cl₂ / 0.5 h / 20 °C

3.1: i-Pr₂NH; n-BuLi / tetrahydrofuran; hexane / 0.08 h / -78 °C

3.2: 62 percent / HMPA / tetrahydrofuran; hexane / 8 h / -78 °C

With titanium(IV) tetraethanolate; n-butyllithium; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-2006-926449