2-{[4,5-bis(benzyloxy)pyridin-2-yl]carbonyl}-N-(cyanomethyl)hydrazinecarboxamide

Base Information

• Chemical Name: 2-{[4,5-bis(benzyloxy)pyridin-2-yl]carbonyl}-N-(cyanomethyl)hydrazinecarboxamide
• CAS No.: 1229937-35-2
• Molecular Formula: C₂₃H₂₁N₅O₄
• Molecular Weight: 431.451
• Mol file: 1229937-35-2.mol

Synonyms:2-{[4,5-bis(benzyloxy)pyridin-2-yl]carbonyl}-N-(cyanomethyl)hydrazinecarboxamide

Chemical Property of 2-{[4,5-bis(benzyloxy)pyridin-2-yl]carbonyl}-N-(cyanomethyl)hydrazinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-{[4,5-bis(benzyloxy)pyridin-2-yl]carbonyl}-N-(cyanomethyl)hydrazinecarboxamide

There total 1 articles about 2-{[4,5-bis(benzyloxy)pyridin-2-yl]carbonyl}-N-(cyanomethyl)hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-(4,5-bis(benzyloxy)pyridin-2-yl)-1,3,4-oxadiazol-2(3H)-one (1229937-09-0) + 2-aminoacetonitrile (540-61-4) → 2-{[4,5-bis(benzyloxy)pyridin-2-yl]carbonyl}-N-(cyanomethyl)hydrazinecarboxamide (1229937-35-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 55 ℃; for 40h;

Reference yield: 52.0%

2-{[4,5-bis(benzyloxy)pyridin-2-yl]carbonyl}-N-(cyanomethyl)hydrazinecarboxamide (1229937-35-2) → {3-[4,5-bis(benzyloxy)pyridin-2-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}acetonitrile (1229937-36-3)

Guidance literature:

With N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; In n-heptane; ethyl acetate; at 150 ℃; for 0.25h; Microwave irradiation;

upstream raw materials:

5-(4,5-bis(benzyloxy)pyridin-2-yl)-1,3,4-oxadiazol-2(3H)-one

2-aminoacetonitrile

Downstream raw materials:

{3-[4,5-bis(benzyloxy)pyridin-2-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}acetonitrile