[(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester

Base Information

• Chemical Name: [(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester
• CAS No.: 132336-35-7
• Molecular Formula: C₃₈H₄₀N₃O₇P
• Molecular Weight: 681.725
• Mol file: 132336-35-7.mol

Synonyms:[(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester

Chemical Property of [(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester

There total 8 articles about [(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-N-benzoylcytosine (26661-13-2) → [(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester (132336-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / dimethylformamide / 5 h / 105 °C

2: NaH / dimethylformamide / 6 h / 0 °C

With sodium hydroxide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)76875-4

Reference yield:

trityl chloride (76-83-5) → [(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester (132336-35-7)

Guidance literature:

Multi-step reaction with 3 steps

1: TEA / CH₂Cl₂ / 3 h / Ambient temperature

2: NaOH / dimethylformamide / 5 h / 105 °C

3: NaH / dimethylformamide / 6 h / 0 °C

With sodium hydroxide; TEA; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)76875-4

Reference yield:

(S)-tritylglycidol (129940-50-7) → [(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester (132336-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / dimethylformamide / 5 h / 105 °C

2: NaH / dimethylformamide / 6 h / 0 °C

With sodium hydroxide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)76875-4

upstream raw materials:

4-N-benzoylcytosine

trityl chloride

(S)-tritylglycidol

(S)-N-(1-(2,3-dihydroxypropyl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

Downstream raw materials:

diethyl (S)-4-N-benzoyl-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine

cidofovir

N⁴-benzoyl-1-(S)-(3-hydroxy-2-phosphonomethoxypropyl)cytosine

lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate