lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

Base Information

• Chemical Name: lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate
• CAS No.: 1312776-47-8
• Molecular Formula: C₃₆H₃₅N₃O₇P*Li
• Molecular Weight: 659.605
• Mol file: 1312776-47-8.mol

Synonyms:lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

Chemical Property of lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

There total 1 articles about lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester (132336-35-7) → lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate (1312776-47-8)

Guidance literature:

With lithium bromide; In acetonitrile; for 40h; Reflux;

DOI:10.1016/j.bmcl.2011.04.126

Reference yield:

lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate (1312776-47-8) → ammonium ethyl ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate (1312776-48-9)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2011.04.126

Reference yield:

lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate (1312776-47-8) → C41H52N5O11P

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / methanol / 16 h / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 40 °C / Inert atmosphere

With ammonium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.04.126

upstream raw materials:

[(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester

Downstream raw materials:

ammonium ethyl ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate