methanesulfonic acid 6-[2-(tert-butyldiphenylsilanyloxy)-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester

Base Information

Chemical Name:methanesulfonic acid 6-[2-(tert-butyldiphenylsilanyloxy)-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester
CAS No.:767344-07-0
Molecular Formula:C₃₈H₄₉NO₇SSi
Molecular Weight:691.961
Hs Code.:

methanesulfonic acid 6-[2-(tert-butyldiphenylsilanyloxy)-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester

Synonyms:methanesulfonic acid 6-[2-(tert-butyldiphenylsilanyloxy)-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester

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Chemical Property of methanesulfonic acid 6-[2-(tert-butyldiphenylsilanyloxy)-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester

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Technology Process of methanesulfonic acid 6-[2-(tert-butyldiphenylsilanyloxy)-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester

There total 5 articles about methanesulfonic acid 6-[2-(tert-butyldiphenylsilanyloxy)-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 767344-21-8
methanesulfonic acid 6-[2-hydroxy-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester

: 767344-07-0
methanesulfonic acid 6-[2-(tert-butyldiphenylsilanyloxy)-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/ol048857e

Reference yield:

: 19676-67-6
2,4-dimethoxy-3-methylphenol

: 767344-07-0
methanesulfonic acid 6-[2-(tert-butyldiphenylsilanyloxy)-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / CF₃CO₂H / CH₂Cl₂ / 2 h / -10 °C

2: 98 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 100 percent / NaBH₄ / methanol; CH₂Cl₂ / 1.5 h / 0 °C

4: 93 percent / imidazole / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol048857e

Reference yield:

: 360778-69-4
agent lactone

: 767344-07-0
methanesulfonic acid 6-[2-(tert-butyldiphenylsilanyloxy)-1-(2-hydroxy-2-methyl-1-phenylpropylamino)ethyl]-2,4-dimethoxy-3-methylphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / CF₃CO₂H / CH₂Cl₂ / 2 h / -10 °C

2: 98 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 100 percent / NaBH₄ / methanol; CH₂Cl₂ / 1.5 h / 0 °C

4: 93 percent / imidazole / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol048857e