6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran

Base Information

Chemical Name:6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran
CAS No.:197706-50-6
Molecular Formula:C₁₁H₁₁FO₂
Molecular Weight:194.206
Hs Code.:
European Community (EC) Number:606-373-1,618-039-2
DSSTox Substance ID:DTXSID301036140
Nikkaji Number:J880.261K
Wikidata:Q76416992

Synonyms:6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran

Suppliers and Price of 6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane
25mg
$ 1230.00

TRC
(2R,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane
2.5mg
$ 155.00

Total 7 raw suppliers

Chemical Property of 6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran

Chemical Property:

Boiling Point:291.7±40.0 °C(Predicted)
Density:1.299±0.06 g/cm3(Predicted)
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:194.07430775
Heavy Atom Count:14
Complexity:221

Purity/Quality:

99.9% ^*data from raw suppliers

(2R,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC2=C(C=CC(=C2)F)OC1C3CO3
Isomeric SMILES:C1CC2=C(C=CC(=C2)F)O[C@H]1[C@H]3CO3
Uses (2R,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane is an intermediate to synthesize Nebivolol (rac, HCl salt, N387900) which is a β1-Adrenergic blocker.

Technology Process of 6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran

There total 26 articles about 6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 303176-46-7
(R)-2-[(R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl-4-methylbenzenesulfonate

: 197706-50-6,793669-26-8,876514-31-7
6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.200800201

Reference yield:

: 793669-26-8,876514-31-7
[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

: 621-84-1
O-benzyl carbamate

: 1029684-22-7
[(S)-2-((S)-6-fluoro-chroman-2-yI)-2-hydroxy-ethyl]-carbamic acid benzyl ester

: 197706-50-6,793669-26-8,876514-31-7
6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran

Guidance literature:: With oxygen; 4-nitro-benzoic acid; [(S,S)-N,N’-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediaminato(2-)]cobalt(II); In methyl tert butyl ester; toluene; at 20 ℃; for 1h; Product distribution / selectivity; Resolution of racemate;