129050-27-7

Basic information

• Product Name: (1S,2R)-2-(2-Benzylamino-1-hydroxyethyl)-6-fluorochromane
• Synonyms: (1S,2R)-2-(2-Benzylamino-1-hydroxyethyl)-6-fluorochromane;(1S)-1-((2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-[(phenylMethyl)aMino]ethanol;(1S,2R)-α-(N-BenzylaMinoMethyl)-6-fluoro-chroMan-2-Methanol;(αS,2R)-6-Fluoro-3,4-dihydro-α-[[(phenylMethyl)a
• CAS NO: 129050-27-7
• Molecular Formula: C18H20FNO2
• Molecular Weight: 301.3553032
• Product Categories: Chiral Reagnts;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 129050-27-7.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 471.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.202±0.06 g/cm3(Predicted)
• Vapor Pressure: 0-0Pa at 20-25℃
• PKA: 14.42±0.20(Predicted)
• CAS DataBase Reference: (1S,2R)-2-(2-Benzylamino-1-hydroxyethyl)-6-fluorochromane(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-2-(2-Benzylamino-1-hydroxyethyl)-6-fluorochromane(129050-27-7)
• EPA Substance Registry System: (1S,2R)-2-(2-Benzylamino-1-hydroxyethyl)-6-fluorochromane(129050-27-7)

Safety Data

• Hazardous Substances Data: 129050-27-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

(-)-Nebivolol intermediate.

Upstream product

• 129050-26-6 (2R)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene 
• 100-46-9 benzylamine 
• 197706-51-7 (S)-6-fluoro-2-((R)-oxiran-2-yl)chroman 
• 1315508-93-0 (R)-2-chloro-1-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol 
• 1219915-00-0 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethanone 
• 197706-50-6 6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran 
• 1219915-05-5 (S)-6-fluoro-2-(oxiran-2-yl)chroman 
• 793669-26-8 [1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 793669-26-8 [1S*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 943126-76-9 C₁₂H₁₁FO₄ 
• 943126-67-8 (+/-)-5-[6-fluorochroman-2-carbonyl]-2, 2-dimethyl[1, 3]dioxane-4, 6-dione 
• 943126-70-3 (+/-)-3-(6-fluorochroman-2-yl)-3-oxo-propionic acid tert-butyl ester 
• 943126-72-5 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one 
• 99199-60-7 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid 

Downstream Products

• 1030385-17-1 (SRRR)-d-N-benzilnebivolol 
• 152520-56-4 DL-nebivolol hydrochloride 
• 1180001-17-5 d-(S,R,R,R)-benzyl nebivolol hydrochloride 
• 897661-66-4 (S*)-2-amino-1-((R*)-6-fluorochroman-2-yl)ethanol 
• 152520-56-4 (+/-)-bis[2-(6-fluorochroman-2-yl)-2-hydroxyethyl]amine hydrochloride 
• 1199945-26-0 2-{benzyl-[2-(6-fluoro-chroman-2-yl)-2-hydroxy-ethyl]-amino}-1-(6-fluoro-chroman-2-yl)-ethanol 
• 1421916-53-1 C₂₉H₃₁F₂NO₄ 

Relevant articles and documents

Synthesis of novel 3-[(2R*)-2-[(2S*)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]-urea/thiourea derivatives and evaluation of their antimicrobial activities

A new series of biologically active 3-[(2R*)-2-[(2S*)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]-urea/thiourea derivatives (1) have been designed and synthesized in four steps from 6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene (2). The structures of newly synthesized compounds (1a–j) were confirmed by 1H, 13C NMR, and HRMS. The major advantages of the present article include the development of an efficient eluent system for good separation of diastereomers (2a and 2b) with high yields and synthesis of (R*)-2-(benzylamino)-1-((S*)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol (3) in high yields (87%) from epoxide (2a) through new reaction conditions. The synthesized compounds (1a–j) exhibited moderate to excellent antimicrobial activities against both bacterial strains (gram + Ve and gram –Ve strains) and fungal strains. Among the tested compounds, promising lead compounds were identified (compounds 1a and 1d against bacterial strains and compound 1h and 1j against fungal strains) and their antimicrobial activities are comparable with the reference standard.

Preparation method and application of Smo inhibitor based on Nebivolol

The invention discloses a preparation method and an application of a Smo inhibitor based on Nebivolol. The structural formula of the Smo inhibitor is as shown in a formula (I). The invention further discloses a synthetic method and an application of the Smo inhibitor. According to the Smo inhibitor, a beta-receptor retardant Nebivolol with inhibitory activity for Smo proteins serves as a lead compound, and optimization reconstruction is implemented based on the beta-receptor retardant Nebivolol to obtain the Smo inhibitor with good inhibitory activity.

Nebivolol synthetic method and intermediate compounds of the

The present invention relates to a synthesis method and an intermediate compound of nebivolol. Specifically the invention relates to the method for synthesizing the nebivolol, the intermediate compound of the nebivolol, and a method for preparing the intermediate compound.