1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol

Base Information

Chemical Name:1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol
CAS No.:1117903-20-4
Molecular Formula:C₃₂H₃₃FN₂O₇
Molecular Weight:576.622
Hs Code.:

Synonyms:1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol

Suppliers and Price of 1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of 1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol

There total 7 articles about 1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 852234-89-0
1,5-anhydro-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1117903-20-4
1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol

Guidance literature:: With pyridine; at 0 - 20 ℃; for 14h;

Reference yield:

: 401906-49-8
1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol

: 1117903-20-4
1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: sodium hydroxide / 1,4-dioxane / 3 h / 65 °C

3: Nonafluorobutanesulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene / 42 h / 35 °C

4: 20% palladium hydroxide on charcoal; hydrogen / methanol / 4 h

5: pyridine / 6 h / 20 °C

With pyridine; Nonafluorobutanesulfonyl fluoride; 20% palladium hydroxide on charcoal; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ja207086x

Reference yield:

: 1117903-17-9
1,5-anhydro-4,6-O-benzylidene-2-deoxy-3-O-methanesulfonyl-2-(thymin-1-yl)-D-altritol

: 1117903-20-4
1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / 1,4-dioxane / 3 h / 65 °C

2: Nonafluorobutanesulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene / 42 h / 35 °C

3: 20% palladium hydroxide on charcoal; hydrogen / methanol / 4 h

4: pyridine / 6 h / 20 °C

With pyridine; Nonafluorobutanesulfonyl fluoride; 20% palladium hydroxide on charcoal; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In 1,4-dioxane; methanol;
DOI:10.1021/ja207086x