401906-49-8

Basic information

• Product Name: 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol
• Synonyms: 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol
• CAS NO: 401906-49-8
• Molecular Weight: 360.367
• Mol File: 401906-49-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol(401906-49-8)
• EPA Substance Registry System: 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol(401906-49-8)

Safety Data

• Hazardous Substances Data: 401906-49-8(Hazardous Substances Data)

Upstream product

• 65-71-4 thymin 
• 92283-88-0 1,5:2,3-dianhydro-4,6-O-benzylidene-D-allitol 

Downstream Products

• 937031-52-2 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(5-methylcytosin-1-yl)-D-altro-hexitol 
• 937031-46-4 1,5-anhydro-4,6-O-benzylidene-2-deoxy-3-O-(9-fluorenylmethoxycarbonyl)-2-(thymin-1-yl)-D-altro-hexitol 
• 1313024-55-3 C₂₄H₃₄N₂O₆Si 
• 1117903-21-5 1,5-anhydro-4-O-(2-cyanoethoxydiisopropylaminophosphinyl)-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol 
• 1117903-20-4 1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol 
• 1117903-19-1 1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol 
• 1117903-18-0 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-mannitol 
• 1117903-22-6 1,5-anhydro-4-O-(tert-butyldimethylsilyl)-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol 
• 1117903-17-9 1,5-anhydro-4,6-O-benzylidene-2-deoxy-3-O-methanesulfonyl-2-(thymin-1-yl)-D-altritol 
• 705967-76-6 1,5-anhydro-4,6-O-benzylidene-2-(N⁴-benzoyl-5-methylcytosin-1-yl)-3-O-tert-butyldimethylsilyl-2-deoxy-D-altro-hexitol 
• 705967-77-7 1,5-anhydro-2-(N⁴-benzoyl-5-methylcytosin-1-yl)-3-O-tert-butyldimethylsilyl-2-deoxy-D-altro-hexitol 
• 705967-75-5 1,5-anhydro-4,6-O-benzylidene-3-O-tert-butyldimethylsilyl-2-deoxy-2-(5-methylcytosin-1-yl)-D-altro-hexitol 
• 705967-72-2 1,5-anhydro-4,6-O-benzylidene-3-O-tert-butyldimethylsilyl-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol 

Relevant articles and documents

Synthesis of D-Altritol Nucleosides with a 3′ -O-Tert-Butyldimethylsilyl Protecting Group

Four D-altritol nucleosides with a 3′-O-tert- butyldimethylsilyl protecting group are synthesized (base moieties are adenine, guanine, thymine and 5-methylcytosine). The nucleosides are obtained by ring opening reaction of 1,5:2,3-dianhydro-4,6-O-benzylid

TETRAHYDROPYRAN NUCLEIC ACID ANALOGS

The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, novel tetrahydropyran nucleoside analogs are provided having at least one chiral substituent that are expected to be useful for enhancing one or more properties of oligomeric compounds such as nuclease resistance and/or binding affinity. In certain embodiments, the oligomeric compounds are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.