401906-49-8

Upstream product

• 65-71-4 thymin 
• 92283-88-0 1,5:2,3-dianhydro-4,6-O-benzylidene-D-allitol 

Downstream Products

• 1117903-21-5 1,5-anhydro-4-O-(2-cyanoethoxydiisopropylaminophosphinyl)-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol 
• 1117903-20-4 1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol 
• 1117903-19-1 1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol 
• 1117903-18-0 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-mannitol 
• 1117903-22-6 1,5-anhydro-4-O-(tert-butyldimethylsilyl)-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-altritol 
• 1313024-55-3 C₂₄H₃₄N₂O₆Si 
• 1117903-17-9 1,5-anhydro-4,6-O-benzylidene-2-deoxy-3-O-methanesulfonyl-2-(thymin-1-yl)-D-altritol 
• 937031-46-4 1,5-anhydro-4,6-O-benzylidene-2-deoxy-3-O-(9-fluorenylmethoxycarbonyl)-2-(thymin-1-yl)-D-altro-hexitol 
• 937031-52-2 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(5-methylcytosin-1-yl)-D-altro-hexitol 
• 705967-76-6 1,5-anhydro-4,6-O-benzylidene-2-(N⁴-benzoyl-5-methylcytosin-1-yl)-3-O-tert-butyldimethylsilyl-2-deoxy-D-altro-hexitol 
• 705967-77-7 1,5-anhydro-2-(N⁴-benzoyl-5-methylcytosin-1-yl)-3-O-tert-butyldimethylsilyl-2-deoxy-D-altro-hexitol 
• 705967-75-5 1,5-anhydro-4,6-O-benzylidene-3-O-tert-butyldimethylsilyl-2-deoxy-2-(5-methylcytosin-1-yl)-D-altro-hexitol 
• 705967-72-2 1,5-anhydro-4,6-O-benzylidene-3-O-tert-butyldimethylsilyl-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol 

Relevant academic research and scientific papers

Synthesis of D-Altritol Nucleosides with a 3′ -O-Tert-Butyldimethylsilyl Protecting Group

Four D-altritol nucleosides with a 3′-O-tert- butyldimethylsilyl protecting group are synthesized (base moieties are adenine, guanine, thymine and 5-methylcytosine). The nucleosides are obtained by ring opening reaction of 1,5:2,3-dianhydro-4,6-O-benzylid

Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3′-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides

The synthesis, biophysical, structural, and biological properties of both isomers of 3′-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides are reported. Synthesis of the FHNA and Ara-FHNA thymine phosphoramidites was efficiently acc

TETRAHYDROPYRAN NUCLEIC ACID ANALOGS

The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, novel tetrahydropyran nucleoside analogs are provided having at least one chiral substituent that are expected to be useful for enhancing one or more properties of oligomeric compounds such as nuclease resistance and/or binding affinity. In certain embodiments, the oligomeric compounds are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

TETRAHYDROPYRAN NUCLEIC ACID ANALOGS

The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral subst